Sp2 transcription factor

SP2
Identifiers
AliasesSP2, Sp2, 4930480I16Rik, mKIAA0048, Sp2 transcription factor
External IDsMGI: 1926162 HomoloGene: 2340 GeneCards: SP2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.32Start47,896,150 bp[1]
End47,928,957 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6668

78912

Ensembl

ENSG00000167182

ENSMUSG00000018678

UniProt

Q02086
Q9BRW5

Q9D2H6

RefSeq (mRNA)

NM_003110

NM_001080964
NM_030220
NM_001363225
NM_001363226

RefSeq (protein)

NP_003101

NP_001074433
NP_084496
NP_001350154
NP_001350155

Location (UCSC)Chr 17: 47.9 – 47.93 MbChr 11: 96.95 – 96.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene.[5][6][7]

Function

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.[7]

Interactions

Sp2 transcription factor has been shown to interact with E2F1.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000167182 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018678 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Kingsley C, Winoto A (Oct 1992). "Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression". Mol Cell Biol. 12 (10): 4251–61. PMC 360348. PMID 1341900.
  6. ↑ Scohy S, Van Vooren P, Szpirer C, Szpirer J (Oct 1998). "Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31→q32.1 (Sp2), 3q24→q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3→q22 by in situ hybridization". Cytogenet Cell Genet. 81 (3–4): 273–4. doi:10.1159/000015044. PMID 9730617.
  7. 1 2 "Entrez Gene: SP2 Sp2 transcription factor".
  8. ↑ Rotheneder H, Geymayer S, Haidweger E (Nov 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281.

Further reading

  • Philipsen S, Suske G (1999). "A tale of three fingers: the family of mammalian Sp/XKLF transcription factors". Nucleic Acids Res. 27 (15): 2991–3000. doi:10.1093/nar/27.15.2991. PMC 148522. PMID 10454592.
  • Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  • Rotheneder H, Geymayer S, Haidweger E (2000). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281.
  • Moorefield KS, Fry SJ, Horowitz JM (2004). "Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells". J. Biol. Chem. 279 (14): 13911–24. doi:10.1074/jbc.M313589200. PMID 14726517.
  • Phan D, Cheng CJ, Galfione M, Vakar-Lopez F, Tunstead J, Thompson NE, Burgess RR, Najjar SM, Yu-Lee LY, Lin SH (2004). "Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis". Cancer Res. 64 (9): 3072–8. doi:10.1158/0008-5472.CAN-03-3730. PMID 15126343.
  • Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J, Robson SC, Europe-Finner GN (2005). "Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases". J. Clin. Endocrinol. Metab. 90 (6): 3479–90. doi:10.1210/jc.2004-1962. PMID 15788387.
  • Lee YC, Higashi Y, Luu C, Shimizu C, Strott CA (2005). "Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition". FEBS Lett. 579 (17): 3639–45. doi:10.1016/j.febslet.2005.05.041. PMID 15953604.
  • Simmons SO, Horowitz JM (2006). "Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells". Biochem. J. 393 (Pt 1): 397–409. doi:10.1042/BJ20051030. PMC 1383699. PMID 16201967.
  • Moorefield KS, Yin H, Nichols TD, Cathcart C, Simmons SO, Horowitz JM (2006). "Sp2 localizes to subnuclear foci associated with the nuclear matrix". Mol. Biol. Cell. 17 (4): 1711–22. doi:10.1091/mbc.E05-11-1063. PMC 1415311. PMID 16467376.
  • Das A, Fernandez-Zapico ME, Cao S, Yao J, Fiorucci S, Hebbel RP, Urrutia R, Shah VH (2007). "Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration". J. Biol. Chem. 281 (51): 39105–13. doi:10.1074/jbc.M607720200. PMID 17071613.
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