ELF4

ELF4
Identifiers
AliasesELF4, ELFR, MEF, E74 like ETS transcription factor 4
External IDsMGI: 1928377 HomoloGene: 31036 GeneCards: ELF4
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq26.1Start130,064,874 bp[1]
End130,110,716 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2000

56501

Ensembl

ENSG00000102034

ENSMUSG00000031103

UniProt

Q99607

Q9Z2U4

RefSeq (mRNA)

NM_001127197
NM_001421

NM_019680

RefSeq (protein)

NP_001120669
NP_001412

NP_062654

Location (UCSC)Chr X: 130.06 – 130.11 MbChr X: 48.41 – 48.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ETS-related transcription factor Elf-4 is a protein that in humans is encoded by the ELF4 gene.[5][6]


References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000102034 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031103 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Miyazaki Y, Sun X, Uchida H, Zhang J, Nimer S (October 1996). "MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties". Oncogene. 13 (8): 1721–9. PMID 8895518.
  6. ↑ "Entrez Gene: ELF4 E74-like factor 4 (ets domain transcription factor)".

Further reading

  • Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A, Nimer SD (April 2006). "The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2". Molecular and Cellular Biology. 26 (8): 3114–23. doi:10.1128/MCB.26.8.3114-3123.2006. PMC 1446966. PMID 16581786.
  • Moore SD, Offor O, Ferry JA, Amrein PC, Morton CC, Dal Cin P (August 2006). "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)". Leukemia Research. 30 (8): 1037–42. doi:10.1016/j.leukres.2005.10.014. PMID 16303180.
  • Lu Z, Kim KA, Suico MA, Shuto T, Li JD, Kai H (March 2004). "MEF up-regulates human beta-defensin 2 expression in epithelial cells". FEBS Letters. 561 (1–3): 117–21. doi:10.1016/S0014-5793(04)00138-3. PMID 15013761.
  • Suico MA, Yoshida H, Seki Y, Uchikawa T, Lu Z, Shuto T, Matsuzaki K, Nakao M, Li JD, Kai H (April 2004). "Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein". The Journal of Biological Chemistry. 279 (18): 19091–8. doi:10.1074/jbc.M312439200. PMID 14976184.
  • Cho JY, Akbarali Y, Zerbini LF, Gu X, Boltax J, Wang Y, Oettgen P, Zhang DE, Libermann TA (May 2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". The Journal of Biological Chemistry. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.
  • Hedvat CV, Yao J, Sokolic RA, Nimer SD (February 2004). "Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells". The Journal of Biological Chemistry. 279 (8): 6395–400. doi:10.1074/jbc.M307524200. PMID 14625302.
  • Suico MA, Koyanagi T, Ise S, Lu Z, Hisatsune A, Seki Y, Shuto T, Isohama Y, Miyata T, Kai H (August 2002). "Functional dissection of the ETS transcription factor MEF". Biochimica et Biophysica Acta. 1577 (1): 113–20. doi:10.1016/s0167-4781(02)00370-6. PMID 12151102.
  • Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD (May 1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Molecular and Cellular Biology. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
  • Aryee DN, Petermann R, Kos K, Henn T, Haas OA, Kovar H (March 1998). "Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1". Gene. 210 (1): 71–8. doi:10.1016/S0378-1119(98)00022-5. PMID 9524226.
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