EGR4

EGR4
Identifiers
AliasesEGR4, NGFI-C, NGFIC, PAT133, early growth response 4, Early growth response protein 4, AT133
External IDsMGI: 99252 HomoloGene: 1485 GeneCards: EGR4
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p13.2Start73,290,929 bp[1]
End73,293,705 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

1961

13656

Ensembl

ENSG00000135625

ENSMUSG00000071341

UniProt

Q05215

Q9WUF2

RefSeq (mRNA)

NM_001965

NM_020596

RefSeq (protein)

NP_001956

NP_065621

Location (UCSC)Chr 2: 73.29 – 73.29 MbChr 6: 85.51 – 85.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Early growth response protein 4 (EGR-4), also known as AT133, is a protein that in humans is encoded by the EGR4 gene.[5]

EGR-4 is a member of the early growth response (EGF) family of zinc finger transcription factors.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000135625 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071341 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: early growth response 4".

Further reading

  • Crosby SD, Veile RA, Donis-Keller H, et al. (1992). "Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C". Proc. Natl. Acad. Sci. U.S.A. 89 (10): 4739–43. doi:10.1073/pnas.89.10.4739. PMC 49159. PMID 1584812.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
  • Müller HJ, Skerka C, Bialonski A, Zipfel PF (November 1991). "Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains". Proc. Natl. Acad. Sci. U.S.A. 88 (22): 10079–83. doi:10.1073/pnas.88.22.10079. PMC 52871. PMID 1658795.
  • Decker EL, Nehmann N, Kampen E, et al. (2003). "Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression". Nucleic Acids Res. 31 (3): 911–21. doi:10.1093/nar/gkg186. PMC 149206. PMID 12560487.
  • Liu BC, Zhang J, Wang L, et al. (2010). "No association between EGR gene family polymorphisms and schizophrenia in the Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 34 (3): 506–9. doi:10.1016/j.pnpbp.2010.02.005. PMID 20144677.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Holst C, Skerka C, Lichter P, et al. (1993). "Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133". Hum. Mol. Genet. 2 (4): 367–72. doi:10.1093/hmg/2.4.367. PMID 8504297.
  • Crosby SD, Puetz JJ, Simburger KS, et al. (1991). "The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family". Mol. Cell. Biol. 11 (8): 3835–41. PMC 361165. PMID 2072895.
  • Hadziselimovic F, Hadziselimovic NO, Demougin P, et al. (2009). "EGR4 is a master gene responsible for fertility in cryptorchidism". Sex Dev. 3 (5): 253–63. doi:10.1159/000249147. PMID 19828938.


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