HEY1

HEY1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DB7
Identifiers
Aliases	HEY1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1, hes related family bHLH transcription factor with YRPW motif 1
External IDs	MGI: 1341800 HomoloGene: 7756 GeneCards: HEY1
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	79,767,863 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	8,667,256 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• microsatellite binding; • DNA binding; • protein dimerization activity; • transcription factor activity, sequence-specific DNA binding; • transcription factor binding; • transcription factor activity, RNA polymerase II core promoter sequence-specific; • protein binding; • transcription factor activity, transcription factor binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • transcription corepressor activity; • sequence-specific DNA binding; • sequence-specific double-stranded DNA binding;
Cellular component	• cytoplasm; • nucleoplasm; • cell nucleus;
Biological process	• dorsal aorta morphogenesis; • pulmonary valve morphogenesis; • negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; • regulation of transcription, DNA-templated; • heart trabecula formation; • regulation of vasculogenesis; • cardiac septum morphogenesis; • ventricular septum morphogenesis; • labyrinthine layer blood vessel development; • negative regulation of transcription from RNA polymerase II promoter; • transcription, DNA-templated; • endocardial cushion morphogenesis; • multicellular organism development; • atrioventricular valve formation; • arterial endothelial cell differentiation; • cellular response to glucocorticoid stimulus; • umbilical cord morphogenesis; • negative regulation of transcription regulatory region DNA binding; • angiogenesis; • negative regulation of transcription, DNA-templated; • cardiac ventricle morphogenesis; • positive regulation of transcription from RNA polymerase II promoter; • negative regulation of Notch signaling pathway; • cardiac epithelial to mesenchymal transition; • Notch signaling involved in heart development; • Notch signaling pathway; • positive regulation of transcription, DNA-templated; • blood vessel development; • heart development; • cell differentiation; • regulation of neurogenesis;
	Sources:Amigo / QuickGO
Orthologs
	23462
	15213
	ENSG00000164683
	ENSMUSG00000040289
	Q9Y5J3
	Q9WV93; Q9QUM5
	NM_012258; NM_001040708; NM_001282851
	NM_010423
	NP_001035798; NP_001269780; NP_036390
	NP_034553
	Wikidata
View/Edit Human	View/Edit Mouse

Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene.^[5]^[6]^[7]

Function

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164683 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040289 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Leimeister C, Externbrink A, Klamt B, Gessler M (Jul 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mechanisms of Development. 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358.
↑ Kokubo H, Lun Y, Johnson RL (Jul 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochemical and Biophysical Research Communications. 260 (2): 459–65. doi:10.1006/bbrc.1999.0880. PMID 10403790.
1 2 "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1".

External links

HEY1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
FactorBook HEY1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164683 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040289 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10415358-5] Leimeister C, Externbrink A, Klamt B, Gessler M (Jul 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mechanisms of Development. 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358.

[pmid10403790-6] Kokubo H, Lun Y, Johnson RL (Jul 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochemical and Biophysical Research Communications. 260 (2): 459–65. doi:10.1006/bbrc.1999.0880. PMID 10403790.

[entrez-7] 1 2 "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1".

HEY1

Function

References

Further reading

External links