ZEB1

ZEB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
External IDsMGI: 1344313 HomoloGene: 31779 GeneCards: ZEB1
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p11.22Start31,318,495 bp[1]
End31,529,814 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6935

21417

Ensembl

ENSG00000148516

ENSMUSG00000024238

UniProt

P37275

Q64318

RefSeq (mRNA)

NM_011546
NM_001360981
NM_001360982

RefSeq (protein)

NP_035676
NP_001347910
NP_001347911

Location (UCSC)Chr 10: 31.32 – 31.53 MbChr 18: 5.59 – 5.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[5][6][7]

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[7][8] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.[9] The structure of the homeodomain shown on the right.

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000148516 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024238 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (September 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
  6. ↑ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
  7. 1 2 "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".
  8. ↑ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
  9. ↑ Bürglin TR, Affolter M (July 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497–521. doi:10.1007/s00412-015-0543-8. PMC 4901127. PMID 26464018.
  10. ↑ Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (April 2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793.

Further reading

  • Franklin AJ, Jetton TL, Shelton KD, Magnuson MA (October 1994). "BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription". Molecular and Cellular Biology. 14 (10): 6773–88. PMC 359208. PMID 7935395.
  • Watanabe Y, Kawakami K, Hirayama Y, Nagano K (December 1993). "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene". Journal of Biochemistry. 114 (6): 849–55. PMID 8138542.
  • Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K (January 1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6". Molecular and Cellular Biology. 18 (1): 10–8. doi:10.1128/mcb.18.1.10. PMC 121442. PMID 9418848.
  • Turner J, Crossley M (September 1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". The EMBO Journal. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
  • Postigo AA, Dean DC (June 1999). "ZEB represses transcription through interaction with the corepressor CtBP". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6683–8. doi:10.1073/pnas.96.12.6683. PMC 21975. PMID 10359772.
  • Hlubek F, Löhberg C, Meiler J, Jung A, Kirchner T, Brabletz T (April 2001). "Tip60 is a cell-type-specific transcriptional regulator". Journal of Biochemistry. 129 (4): 635–41. doi:10.1093/oxfordjournals.jbchem.a002901. PMID 11275565.
  • Locklin RM, Riggs BL, Hicok KC, Horton HF, Byrne MC, Khosla S (December 2001). "Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology". Journal of Bone and Mineral Research. 16 (12): 2192–204. doi:10.1359/jbmr.2001.16.12.2192. PMID 11760832.
  • Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S (2002). "Effects of HIV-1 Nef on cellular gene expression profiles". Journal of Biomedical Science. 9 (1): 82–96. doi:10.1007/BF02256581. PMID 11810028.
  • Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J (October 2002). "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression". The Journal of Biological Chemistry. 277 (42): 39209–16. doi:10.1074/jbc.M206400200. PMID 12161443.
  • Costantino ME, Stearman RP, Smith GE, Darling DS (August 2002). "Cell-specific phosphorylation of Zfhep transcription factor". Biochemical and Biophysical Research Communications. 296 (2): 368–73. doi:10.1016/S0006-291X(02)00880-X. PMC 3682420. PMID 12163027.
  • Postigo AA (May 2003). "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway". The EMBO Journal. 22 (10): 2443–52. doi:10.1093/emboj/cdg225. PMC 155983. PMID 12743038.
  • Postigo AA, Depp JL, Taylor JJ, Kroll KL (May 2003). "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins". The EMBO Journal. 22 (10): 2453–62. doi:10.1093/emboj/cdg226. PMC 155984. PMID 12743039.
  • Dillner NB, Sanders MM (January 2004). "Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades". DNA and Cell Biology. 23 (1): 25–34. doi:10.1089/104454904322745907. PMID 14965470.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Shimizu S, Krafchak C, Fuse N, Epstein MP, Schteingart MT, Sugar A, Eibschitz-Tsimhoni M, Downs CA, Rozsa F, Trager EH, Reed DM, Boehnke M, Moroi SE, Richards JE (November 2004). "A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10". American Journal of Medical Genetics. Part A. 130A (4): 372–7. doi:10.1002/ajmg.a.30267. PMC 1249494. PMID 15384081.
  • Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R (March 2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells". Oncogene. 24 (14): 2375–85. doi:10.1038/sj.onc.1208429. PMID 15674322.
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