MEIS2

MEIS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMEIS2, HsT18361, MRG1, Meis homeobox 2, CPCMR
External IDsMGI: 108564 HomoloGene: 7846 GeneCards: MEIS2
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q14Start36,889,204 bp[1]
End37,101,299 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4212

17536

Ensembl

ENSG00000134138

ENSMUSG00000027210

UniProt

O14770

P97367

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 15: 36.89 – 37.1 MbChr 2: 115.86 – 116.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.[5][6]

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000134138 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027210 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Smith JE, Afonja O, Yee HT, Inghirami G, Takeshita K (Jan 1998). "Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene". Mamm Genome. 8 (12): 951–2. doi:10.1007/s003359900621. PMID 9383298.
  6. 1 2 "Entrez Gene: MEIS2 Meis homeobox 2".

Further reading

  • Hui H, Perfetti R (2002). "Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood". Eur. J. Endocrinol. 146 (2): 129–41. doi:10.1530/eje.0.1460129. PMID 11834421.
  • Steelman S, Moskow JJ, Muzynski K, et al. (1997). "Identification of a conserved family of Meis1-related homeobox genes". Genome Res. 7 (2): 142–56. doi:10.1101/gr.7.2.142. PMID 9049632.
  • Capdevila J, Tsukui T, Rodríquez Esteban C, et al. (2000). "Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin". Mol. Cell. 4 (5): 839–49. doi:10.1016/S1097-2765(00)80393-7. PMID 10619030.
  • Yang Y, Hwang CK, D'Souza UM, et al. (2000). "Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription". J. Biol. Chem. 275 (27): 20734–41. doi:10.1074/jbc.M908382199. PMID 10764806.
  • Liu Y, MacDonald RJ, Swift GH (2001). "DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex". J. Biol. Chem. 276 (21): 17985–93. doi:10.1074/jbc.M100678200. PMID 11279116.
  • Fujino T, Yamazaki Y, Largaespada DA, et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Exp. Hematol. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Dintilhac A, Bihan R, Guerrier D, et al. (2004). "A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis". Gene Expr. Patterns. 4 (2): 215–22. doi:10.1016/j.modgep.2003.08.006. PMID 15161102.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.