Intracellular receptor

Intracellular receptors are receptors located inside the cell rather than on its cell membrane. Classic hormones that use intracellular receptors include thyroid and steroid hormones. Examples are the class of nuclear receptors located in the cell nucleus and cytoplasm and the IP₃ receptor located on the endoplasmic reticulum. The ligands that bind to them are usually intracellular second messengers like inositol trisphosphate (IP₃) and extracellular lipophilic hormones like steroid hormones. Some intracrine peptide hormones also have intracellular receptors.

Examples

• transcription factors
  • nuclear receptors
• other
  • Sigma₁ (neurosteroids)
  • IP₃ receptor (inositol triphosphate, IP₃)

See also

• Receptor
• Steroid hormone

External links

• Nuclear Receptor journal homepage
• Nuclear receptor resource at Georgetown University
• Nuclear receptor signalling atlas (NURSA, open-access journal)