HIVEP2

HIVEP2
Identifiers
AliasesHIVEP2, HIV-EP2, MBP-2, MIBP1, SHN2, ZAS2, ZNF40B, human immunodeficiency virus type I enhancer binding protein 2, MRD43
External IDsMGI: 1338076 HomoloGene: 4900 GeneCards: HIVEP2
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q24.2Start142,751,467 bp[1]
End142,956,698 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3097

15273

Ensembl

ENSG00000010818

ENSMUSG00000015501

UniProt

P31629

Q3UHF7

RefSeq (mRNA)

NM_006734

NM_010437
NM_001358782
NM_001358783

RefSeq (protein)

NP_006725

NP_034567
NP_001345711
NP_001345712

Location (UCSC)Chr 6: 142.75 – 142.96 MbChr 10: 13.97 – 14.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor HIVEP2 is a protein that in humans is encoded by the HIVEP2 gene.[5][6][7]

Function

Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000010818 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015501 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Sudo T, Ozawa K, Soeda EI, Nomura N, Ishii S (January 1992). "Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24". Genomics. 12 (1): 167–70. doi:10.1016/0888-7543(92)90423-P. PMID 1733857.
  6. ↑ Nomura N, Zhao MJ, Nagase T, Maekawa T, Ishizaki R, Tabata S, Ishii S (May 1991). "HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1". The Journal of Biological Chemistry. 266 (13): 8590–4. PMID 2022670.
  7. 1 2 "Entrez Gene: HIVEP2 human immunodeficiency virus type I enhancer binding protein 2".

Further reading

  • van 't Veer LJ, Lutz PM, Isselbacher KJ, Bernards R (October 1992). "Structure and expression of major histocompatibility complex-binding protein 2, a 275-kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class I genes". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 8971–5. doi:10.1073/pnas.89.19.8971. PMC 50046. PMID 1409593.
  • Rustgi AK, Van 't Veer LJ, Bernards R (November 1990). "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties". Proceedings of the National Academy of Sciences of the United States of America. 87 (22): 8707–10. doi:10.1073/pnas.87.22.8707. PMC 55028. PMID 2247438.
  • Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Dörflinger U, Pscherer A, Moser M, Rümmele P, Schüle R, Buettner R (May 1999). "Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain". Molecular and Cellular Biology. 19 (5): 3736–47. PMC 84194. PMID 10207097.
  • Zajac-Kaye M, Ben-Baruch N, Kastanos E, Kaye FJ, Allegra C (February 2000). "Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells". The Biochemical Journal. 345 (3): 535–41. doi:10.1042/0264-6021:3450535. PMC 1220788. PMID 10642512.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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