NFIX

NFIX
Identifiers
AliasesNFIX, MRSHSS, NF1A, SOTOS2, nuclear factor I X, NF1-X, NF-I/X, CTF
External IDsMGI: 97311 HomoloGene: 1872 GeneCards: NFIX
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.13Start12,995,608 bp[1]
End13,098,796 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4784

18032

Ensembl

ENSG00000008441

ENSMUSG00000001911

UniProt

Q14938

P70257

RefSeq (mRNA)

NM_001271043
NM_001271044
NM_002501

NM_001081981
NM_001081982
NM_001297601
NM_010906

RefSeq (protein)

NP_001257972
NP_001257973
NP_002492

NP_001075450
NP_001075451
NP_001284530
NP_035036

Location (UCSC)Chr 19: 13 – 13.1 MbChr 8: 84.7 – 84.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene.[5][6][7] NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.[8]

Interactions

NFIX has been shown to interact with SKI protein[9] and it is also known to interact with AP-1.[8] NFI-X3 has been shown to interact with STAT3.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000008441 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001911 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Seisenberger C, Winnacker EL, Scherthan H (Aug 1993). "Localisation of the human nuclear factor I/X (NFI/X) gene to chromosome 19p13 and detection of five other related loci at 1p21-22, 1q42-43, 5q15, 11p13 and 20q13 by FISH". Hum Genet. 91 (6): 535–7. doi:10.1007/bf00205076. PMID 8340106.
  6. ↑ Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
  7. ↑ "Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)".
  8. 1 2 3 Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, Kordula T (November 2011). "A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40". J. Biol. Chem. 286 (46): 39893–903. doi:10.1074/jbc.M111.257451. PMC 3220556. PMID 21953450.
  9. ↑ Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E (October 1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI". Nucleic Acids Res. 25 (19): 3895–903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514.

Further reading

  • Apt D, Liu Y, Bernard HU (1994). "Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner". Nucleic Acids Res. 22 (19): 3825–33. doi:10.1093/nar/22.19.3825. PMC 308376. PMID 7937100.
  • Sumner C, Shinohara T, Durham L, Traub R, Major EO, Amemiya K (1996). "Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes". J. Neurovirol. 2 (2): 87–100. doi:10.3109/13550289609146542. PMID 8799200.
  • Wendler WM, Kremmer E, Förster R, Winnacker EL (1997). "Identification of pirin, a novel highly conserved nuclear protein". J. Biol. Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.
  • Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724.
  • Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E (1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI". Nucleic Acids Res. 25 (19): 3895–903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514.
  • Müller K, Mermod N (2000). "The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo". J. Biol. Chem. 275 (3): 1645–50. doi:10.1074/jbc.275.3.1645. PMID 10636857.
  • Nakazato M, Chung HK, Ulianich L, Grassadonia A, Suzuki K, Kohn LD (2000). "Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression". Mol. Cell. Biol. 20 (22): 8499–512. doi:10.1128/MCB.20.22.8499-8512.2000. PMC 102156. PMID 11046146.
  • Imagawa M, Sakaue R, Tanabe A, Osada S, Nishihara T (2000). "Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A". FEBS Lett. 484 (2): 118–24. doi:10.1016/S0014-5793(00)02119-0. PMID 11068044.
  • Norquay LD, Yang X, Sheppard P, Gregoire S, Dodd JG, Reith W, Cattini PA (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117.
  • Gopalan SM, Wilczynska KM, Konik BS, Bryan L, Kordula T (2006). "Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes". J. Biol. Chem. 281 (19): 13126–33. doi:10.1074/jbc.M601194200. PMID 16565071.
  • Ravichandran V, Sabath BF, Jensen PN, Houff SA, Major EO (2006). "Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism". J. Virol. 80 (21): 10506–13. doi:10.1128/JVI.01355-06. PMC 1641797. PMID 16928756.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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