IRX4

IRX4
Identifiers
AliasesIRX4, IRXA3, iroquois homeobox 4
External IDsMGI: 1355275 HomoloGene: 9485 GeneCards: IRX4
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5p15.33Start1,877,413 bp[1]
End1,887,236 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

50805

50916

Ensembl

ENSG00000113430

ENSMUSG00000021604

UniProt

P78413

Q9QY61

RefSeq (mRNA)

NM_016358
NM_001278632
NM_001278633
NM_001278634
NM_001278635

NM_018885

RefSeq (protein)

NP_001265561
NP_001265562
NP_001265563
NP_001265564
NP_057442

NP_061373

Location (UCSC)Chr 5: 1.88 – 1.89 MbChr 13: 73.26 – 73.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.[5][6]

Function

IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113430 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021604 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: iroquois homeobox 4".
  6. ↑ Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE (January 2000). "Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand". Dev. Biol. 217 (2): 266–77. doi:10.1006/dbio.1999.9548. PMID 10625552.

Further reading

  • Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142.
  • Wang GF, Nikovits W, Bao ZZ, Stockdale FE (2001). "Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression". J. Biol. Chem. 276 (31): 28835–41. doi:10.1074/jbc.M103716200. PMID 11382777.
  • Bayrak F, Kömürcü-Bayrak E, Mutlu B, et al. (2008). "Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy". Turk Kardiyol Dern Ars. 36 (2): 90–5. PMID 18497553.
  • Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests". European Journal of Human Genetics. 18 (7): HASH(0x24ee8d0). doi:10.1038/ejhg.2010.2. PMC 2987367. PMID 20125193.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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