SOX15

SOX15
Identifiers
Aliases	SOX15, SOX20, SOX26, SOX27, SRY-box 15
External IDs	MGI: 98363 HomoloGene: 74586 GeneCards: SOX15
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	7,590,170 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	69,656,727 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • transcription factor activity, sequence-specific DNA binding; • chromatin binding; • protein binding; • protein heterodimerization activity; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;
Cellular component	• cytoplasm; • nuclear transcription factor complex; • cell nucleus;
Biological process	• positive regulation of myoblast proliferation; • cell differentiation; • male gonad development; • regulation of transcription, DNA-templated; • positive regulation of satellite cell activation involved in skeletal muscle regeneration; • negative regulation of striated muscle tissue development; • regulation of transcription from RNA polymerase II promoter; • positive regulation of G0 to G1 transition; • negative regulation of transcription from RNA polymerase II promoter; • chromatin organization; • myoblast development; • skeletal muscle tissue regeneration; • positive regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	6665
	20670
	ENSG00000129194
	ENSMUSG00000041287
	O60248
	P43267
	NM_006942
	NM_009235
	NP_008873
	NP_033261
	Wikidata
View/Edit Human	View/Edit Mouse

Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene.^[5]^[6]^[7]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000129194 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041287 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Meyer J, Wirth J, Held M, Schempp W, Scherer G (Jan 1997). "SOX20, a new member of the SOX gene family, is located on chromosome 17p13". Cytogenet Cell Genet. 72 (2–3): 246–9. doi:10.1159/000134200. PMID 8978787.
↑ Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (Oct 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625.
1 2 "Entrez Gene: SOX15 SRY (sex determining region Y)-box 15".

Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Dev. Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Res. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMC 309692. PMID 8332506.
Hiraoka Y, Ogawa M, Sakai Y, et al. (1998). "Isolation and expression of a human SRY-related cDNA hSOX20". Biochim. Biophys. Acta. 1396 (2): 132–7. doi:10.1016/s0167-4781(97)00186-3. PMID 9540826.
Cremazy F, Soullier S, Berta P, Jay P (1998). "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR". FEBS Lett. 438 (3): 311–4. doi:10.1016/S0014-5793(98)01294-0. PMID 9827568.
Vujić M, Rajić T, Goodfellow PN, Stevanović M (1999). "cDNA characterization and high resolution mapping of the human SOX20 gene". Mamm. Genome. 9 (12): 1059–61. doi:10.1007/s003359900925. PMID 9880678.
Miyashita A, Shimizu N, Endo N, et al. (1999). "Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11". Gene. 237 (1): 53–60. doi:10.1016/S0378-1119(99)00301-7. PMID 10524236.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000129194 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041287 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8978787-5] Meyer J, Wirth J, Held M, Schempp W, Scherer G (Jan 1997). "SOX20, a new member of the SOX gene family, is located on chromosome 17p13". Cytogenet Cell Genet. 72 (2–3): 246–9. doi:10.1159/000134200. PMID 8978787.

[pmid9730625-6] Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (Oct 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625.

[entrez-7] 1 2 "Entrez Gene: SOX15 SRY (sex determining region Y)-box 15".

SOX15

See also

References

Further reading