HES6

HES6
Identifiers
Aliases	HES6, C-HAIRY1, HES-6, bHLHb41, bHLHc23, hes family bHLH transcription factor 6
External IDs	MGI: 1859852 HomoloGene: 23111 GeneCards: HES6
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	238,240,662 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	91,414,038 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • transcription factor binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • protein dimerization activity; • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding; • transcription factor activity, sequence-specific DNA binding; • transcription cofactor activity; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • transcription corepressor activity; • sequence-specific DNA binding; • sequence-specific double-stranded DNA binding;
Cellular component	• cell nucleus; • transcription factor complex;
Biological process	• regulation of transcription from RNA polymerase II promoter; • multicellular organism development; • cell differentiation; • negative regulation of transcription from RNA polymerase II promoter; • transcription, DNA-templated; • nervous system development; • regulation of transcription, DNA-templated; • somitogenesis; • Notch signaling pathway; • regulation of neurogenesis;
	Sources:Amigo / QuickGO
Orthologs
	55502
	55927
	ENSG00000144485
	ENSMUSG00000067071
	Q96HZ4
	Q9JHE6
	NM_018645; NM_001142853; NM_001282434
	NM_019479; NM_001360899; NM_001360900
	NP_001136325; NP_001269363; NP_061115
	NP_062352; NP_001347828; NP_001347829
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.^[5]^[6]

Interactions

HES6 has been shown to interact with TLE1.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000144485 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067071 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. PMID 10851137.
↑ "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)".
↑ Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.

External links

HES6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000144485 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067071 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10851137-5] Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. PMID 10851137.

[entrez-6] "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)".

[pmid11551980-7] Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.

HES6

Interactions

References

Further reading

External links