ZNF43

ZNF43
Identifiers
AliasesZNF43, HTF6, KOX27, ZNF39L1, zinc finger protein 43
External IDsMGI: 3040691 HomoloGene: 128170 GeneCards: ZNF43
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p12Start21,804,949 bp[1]
End21,852,125 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7594

238690

Ensembl

ENSG00000198521
ENSG00000279566

ENSMUSG00000055480

UniProt

P17038

Q6P5C7

RefSeq (mRNA)

NM_001001152

RefSeq (protein)

NP_001001152

Location (UCSC)Chr 19: 21.8 – 21.85 MbChr 13: 67.25 – 67.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 43 is a protein that in humans is encoded by the ZNF43 gene.[5][6]

Function

This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions.[6]

See also

References

  1. 1 2 3 ENSG00000279566 GRCh38: Ensembl release 89: ENSG00000198521, ENSG00000279566 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055480 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Lovering R, Trowsdale J (Jun 1991). "A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines". Nucleic Acids Research. 19 (11): 2921–8. doi:10.1093/nar/19.11.2921. PMC 328252. PMID 1711675.
  6. 1 2 "Entrez Gene: ZNF43 zinc finger protein 43".

Further reading

  • Huebner K, Druck T, Croce CM, Thiesen HJ (Apr 1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". American Journal of Human Genetics. 48 (4): 726–40. PMC 1682948. PMID 2014798.
  • Bellefroid EJ, Poncelet DA, Lecocq PJ, Revelant O, Martial JA (May 1991). "The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3608–12. doi:10.1073/pnas.88.9.3608. PMC 51501. PMID 2023909.
  • Thiesen HJ (Apr 1990). "Multiple genes encoding zinc finger domains are expressed in human T cells". The New Biologist. 2 (4): 363–74. PMID 2288909.
  • Bellefroid EJ, Marine JC, Ried T, Lecocq PJ, Rivière M, Amemiya C, Poncelet DA, Coulie PG, de Jong P, Szpirer C (Apr 1993). "Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells". The EMBO Journal. 12 (4): 1363–74. PMC 413348. PMID 8467795.
  • Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Takahashi T, Furuchi T, Naganuma A (Dec 2006). "Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells". Cancer Research. 66 (24): 11932–7. doi:10.1158/0008-5472.CAN-06-3220. PMID 17178891.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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