E2F4

E2F4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CF7
Identifiers
Aliases	E2F4, E2F-4, E2F transcription factor 4
External IDs	MGI: 103012 HomoloGene: 1471 GeneCards: E2F4
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,192,169 bp[1] End 67,198,918 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 105,297,663 bp[2] End 105,305,370 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • protein domain specific binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • promoter-specific chromatin binding • protein dimerization activity • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • sequence-specific DNA binding Cellular component • transcription factor complex • nucleoplasm • nuclear chromatin • cell nucleus • RNA polymerase II transcription factor complex Biological process • regulation of cell size • epithelial cell development • cell volume homeostasis • regulation of transcription, DNA-templated • multi-ciliated epithelial cell differentiation • transcription from RNA polymerase II promoter • regulation of transcription involved in G1/S transition of mitotic cell cycle • blood circulation • cell projection organization • regulation of cell proliferation • animal organ morphogenesis • cell cycle • motile cilium assembly • centriole assembly • transcription, DNA-templated • mitotic cell cycle • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • positive regulation of transcription from RNA polymerase II promoter • cilium morphogenesis • negative regulation of transcription from RNA polymerase II promoter • regulation of cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1874	104394
Ensembl	ENSG00000205250	ENSMUSG00000014859
UniProt	Q16254	Q8R0K9
RefSeq (mRNA)	NM_001950	NM_148952
RefSeq (protein)	NP_001941	NP_683754
Location (UCSC)	Chr 16: 67.19 – 67.2 Mb	Chr 8: 105.3 – 105.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene.^[5][6]

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.^[7]

Structure

The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids (Asp + Glu), and a tumor suppressor protein association domain which is embedded within the transactivation domain.

Interactions

E2F4 has been shown to interact with Smad3.^[8]

See also

• E2F

References

Further reading

External links

• E2F4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook E2F4

This article incorporates text from the United States National Library of Medicine, which is in the public domain.