TAL2

TAL2
Identifiers
AliasesTAL2, TAL bHLH transcription factor 2
External IDsMGI: 99540 HomoloGene: 3954 GeneCards: TAL2
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q31.2Start105,662,457 bp[1]
End105,663,112 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

6887

21350

Ensembl

ENSG00000186051

ENSMUSG00000028417

UniProt

Q16559

Q62282

RefSeq (mRNA)

NM_005421

NM_009317

RefSeq (protein)

NP_005412

NP_033343

Location (UCSC)Chr 9: 105.66 – 105.66 MbChr 4: 53.78 – 53.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.[5][6]

Function

TAL2 is a member of the basic helix-loop-helix family of transcription factors.[7]

Clinical significance

Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).[6][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000186051 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028417 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2".
  6. 1 2 Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
  7. ↑ Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia". Semin. Cancer Biol. 4 (6): 341–7. PMID 8142619.
  8. ↑ Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B (March 2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187.

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Marculescu R, Vanura K, Le T, et al. (2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Xia Y, Hwang LY, Cobb MH, Baer R (1994). "Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity". Oncogene. 9 (5): 1437–46. PMID 8152805.
  • Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. PMC 395422. PMID 7957052.
  • Xia Y, Brown L, Yang CY, et al. (1992). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
  • Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein". Blood. 80 (11): 2858–66. PMID 1450410.


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