NKX6-2

NKX6-2
Identifiers
Aliases	NKX6-2, GTX, NKX6.2, NKX6B, NK6 homeobox 2, SPAX8
External IDs	MGI: 1352738 HomoloGene: 18580 GeneCards: NKX6-2
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	132,786,052 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	139,582,797 bp[2]
Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding; • RNA polymerase II core promoter proximal region sequence-specific DNA binding; • sequence-specific DNA binding; • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • DNA binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding;
Cellular component	• cell nucleus;
Biological process	• multicellular organism development; • positive regulation of glial cell differentiation; • cell differentiation; • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; • oligodendrocyte differentiation; • negative regulation of glial cell differentiation; • regulation of transcription, DNA-templated; • negative regulation of transcription from RNA polymerase II promoter; • negative regulation of cell fate commitment; • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; • neuromuscular process controlling balance; • positive regulation of cell fate commitment; • central nervous system myelination; • endocrine pancreas development; • regulation of myelination; • negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	84504
	14912
	ENSG00000148826
	ENSMUSG00000041309
	Q9C056
	D3Z4R4
	NM_177400
	NM_183248
	NP_796374
	NP_899071
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-6.2 is a protein that in humans is encoded by the NKX6-2 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148826 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041309 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Lee SH, Davison JA, Vidal SM, Belouchi A (February 2001). "Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors". Mamm. Genome. 12 (2): 157–62. doi:10.1007/s003350010247. PMID 11210186.
↑ "Entrez Gene: NK6 homeobox 2".

NKX6-2

References

Further reading