ZNF346

ZNF346
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZNF346, JAZ, Zfp346, zinc finger protein 346
External IDsMGI: 1349417 HomoloGene: 8073 GeneCards: ZNF346
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q35.2Start177,022,696 bp[1]
End177,081,189 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23567

26919

Ensembl

ENSG00000113761

ENSMUSG00000021481

UniProt

Q9UL40

Q9R0B7

RefSeq (mRNA)

NM_012017

RefSeq (protein)

NP_036147

Location (UCSC)Chr 5: 177.02 – 177.08 MbChr 13: 55.11 – 55.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.[5][6]

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113761 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021481 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Yang M, May WS, Ito T (Nov 1999). "JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization". J Biol Chem. 274 (39): 27399–406. doi:10.1074/jbc.274.39.27399. PMID 10488071.
  6. 1 2 "Entrez Gene: ZNF346 zinc finger protein 346".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Chen T, Brownawell AM, Macara IG (2004). "Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5". Mol. Cell. Biol. 24 (15): 6608–19. doi:10.1128/MCB.24.15.6608-6619.2004. PMC 444848. PMID 15254228.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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