NKX6-1

NKX6-1
Identifiers
Aliases	NKX6-1, NKX6.1, NKX6A, NK6 homeobox 1
External IDs	MGI: 1206039 HomoloGene: 4495 GeneCards: NKX6-1
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	84,498,450 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	101,664,996 bp[2]
Gene ontology
Molecular function	• transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • sequence-specific DNA binding; • RNA polymerase II core promoter proximal region sequence-specific DNA binding; • chromatin binding; • transcription factor activity, sequence-specific DNA binding; • DNA binding;
Cellular component	• cell nucleus; • extracellular exosome;
Biological process	• smoothened signaling pathway; • detection of glucose; • pancreas development; • transcription, DNA-templated; • regulation of axon extension; • multicellular organism development; • cellular response to peptide hormone stimulus; • central nervous system neuron differentiation; • response to nicotine; • negative regulation of glial cell differentiation; • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; • type B pancreatic cell proliferation; • cellular response to cytokine stimulus; • positive regulation of sequence-specific DNA binding transcription factor activity; • neurogenesis; • regulation of transcription from RNA polymerase II promoter; • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; • type B pancreatic cell development; • positive regulation of neuron differentiation; • negative regulation of transcription from RNA polymerase II promoter; • positive regulation of type B pancreatic cell development; • type B pancreatic cell maturation; • oligodendrocyte differentiation; • regulation of transcription, DNA-templated; • cell proliferation; • positive regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter; • response to drug; • positive regulation of glial cell differentiation; • cell differentiation; • positive regulation of insulin secretion; • animal organ morphogenesis; • regulation of neuron migration; • neuron migration; • regulation of insulin secretion; • endocrine pancreas development; • type B pancreatic cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	4825
	18096
	ENSG00000163623
	ENSMUSG00000035187
	P78426
	Q99MA9
	NM_006168
	NM_144955
	NP_006159
	NP_659204
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.^[5]^[6]

Function

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163623 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035187 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics. 40 (2): 367–70. doi:10.1006/geno.1996.4568. PMID 9119408.
1 2 "Entrez Gene: NK6 homeobox 1".

Schisler JC, Fueger PT, Babu DA, et al. (2008). "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1". Mol. Cell. Biol. 28 (10): 3465–76. doi:10.1128/MCB.01791-07. PMC 2423154. PMID 18347054.
Hori Y, Gu X, Xie X, Kim SK (2005). "Differentiation of insulin-producing cells from human neural progenitor cells". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736.
Jørgensen MC, Vestergírd Petersen H, Ericson J, et al. (1999). "Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1". FEBS Lett. 461 (3): 287–94. doi:10.1016/S0014-5793(99)01436-2. PMID 10567713.
Iype T, Taylor DG, Ziesmann SM, et al. (2004). "The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1". Mol. Endocrinol. 18 (6): 1363–75. doi:10.1210/me.2004-0006. PMID 15056733.
Yokoi N, Kanamori M, Horikawa Y, et al. (2006). "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects". Diabetes. 55 (8): 2379–86. doi:10.2337/db05-1203. PMID 16873704.
Zhu S, Xia HH, Yang Y, et al. (2009). "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia". Dig. Dis. Sci. 54 (5): 996–1002. doi:10.1007/s10620-008-0459-8. PMID 18754095.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163623 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035187 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid9119408-5] Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics. 40 (2): 367–70. doi:10.1006/geno.1996.4568. PMID 9119408.

[entrez-6] 1 2 "Entrez Gene: NK6 homeobox 1".

NKX6-1

Function

References

Further reading