KLF8

KLF8
Identifiers
AliasesKLF8, BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8
External IDsMGI: 2442430 HomoloGene: 68549 GeneCards: KLF8
Gene location (Human)
Chr.X chromosome (human)[1]
BandXp11.21Start56,232,421 bp[1]
End56,287,889 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11279

245671

Ensembl

ENSG00000102349

ENSMUSG00000041649

UniProt

O95600

Q8BLM0

RefSeq (mRNA)

NM_173780
NM_001357183

RefSeq (protein)

NP_776141
NP_001344112

Location (UCSC)Chr X: 56.23 – 56.29 MbChr X: 153.24 – 153.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.[5]

Interactions

KLF8 has been shown to interact with CTBP2.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000102349 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041649 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: KLF8 Kruppel-like factor 8".
  6. ↑ van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.

Further reading

  • van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.
  • Lossi AM, Laugier-Anfossi F, Depetris D, Gecz J, Gedeon A, Kooy F, Schwartz C, Mattei MG, Croquette MF, Villard L (Feb 2002). "Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation". Journal of Medical Genetics. 39 (2): 113–7. doi:10.1136/jmg.39.2.113. PMC 1735036. PMID 11836360.
  • Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (Apr 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". The Journal of Biological Chemistry. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.
  • Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL (Jun 2003). "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression". Molecular Cell. 11 (6): 1503–15. doi:10.1016/S1097-2765(03)00179-5. PMID 12820964.
  • Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells, Molecules & Diseases. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
  • Wang X, Zhao J (Jan 2007). "KLF8 transcription factor participates in oncogenic transformation". Oncogene. 26 (3): 456–61. doi:10.1038/sj.onc.1209796. PMID 16832343.
  • Hu JH, Navas P, Cao H, Stamatoyannopoulos G, Song CZ (Mar 2007). "Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation". Journal of Molecular Biology. 366 (4): 1064–73. doi:10.1016/j.jmb.2006.12.047. PMC 1907364. PMID 17224162.
  • Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J (Aug 2007). "Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion". Cancer Research. 67 (15): 7184–93. doi:10.1158/0008-5472.CAN-06-4729. PMID 17671186.
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