BCL11B

BCL11B
Identifiers
AliasesBCL11B, ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, CTIP-2, CTIP2, RIT1, ZNF856B, hRIT1-alpha, B-cell CLL/lymphoma 11B, IMD49, B cell CLL/lymphoma 11B
External IDsMGI: 1929913 HomoloGene: 10974 GeneCards: BCL11B
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q32.2Start99,169,287 bp[1]
End99,271,524 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64919

58208

Ensembl

ENSG00000127152

ENSMUSG00000048251

UniProt

Q9C0K0

Q99PV8

RefSeq (mRNA)

NM_001282237
NM_001282238
NM_022898
NM_138576

NM_001079883
NM_001286343
NM_021399

RefSeq (protein)

NP_001269166
NP_001269167
NP_075049
NP_612808

NP_001073352
NP_001273272
NP_067374

Location (UCSC)Chr 14: 99.17 – 99.27 MbChr 12: 107.91 – 108 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.[5][6][7]

Function

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined, but it could also be involved in some malignancies. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.[7]

Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly.[8]

Interactions

BCL11B has been shown to interact with COUP-TFI.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000127152 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048251 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG, Siebert R, Tucker PW, Dyer MJ (Nov 2001). "The BCL11 gene family: involvement of BCL11A in lymphoid malignancies". Blood. 98 (12): 3413–20. doi:10.1182/blood.V98.12.3413. PMID 11719382.
  6. ↑ Topark-Ngarm A, Golonzhka O, Peterson VJ, Barrett B, Martinez B, Crofoot K, Filtz TM, Leid M (Oct 2006). "CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene". J. Biol. Chem. 281 (43): 32272–83. doi:10.1074/jbc.M602776200. PMC 2547407. PMID 16950772.
  7. 1 2 "Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)".
  8. ↑ Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M (March 2009). "Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis". Proc. Natl. Acad. Sci. U.S.A. 106 (11): 4278–83. doi:10.1073/pnas.0900568106. PMC 2657370. PMID 19251658. Lay summary – BBC News.
  9. ↑ Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (April 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.

Further reading

  • Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
  • Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M (2002). "COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein". Biochem. J. 368 (Pt 2): 555–63. doi:10.1042/BJ20020496. PMC 1223006. PMID 12196208.
  • Wakabayashi Y, Inoue J, Takahashi Y, Matsuki A, Kosugi-Okano H, Shinbo T, Mishima Y, Niwa O, Kominami R (2003). "Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas". Biochem. Biophys. Res. Commun. 301 (2): 598–603. doi:10.1016/S0006-291X(02)03069-3. PMID 12565905.
  • Rohr O, Lecestre D, Chasserot-Golaz S, Marban C, Avram D, Aunis D, Leid M, Schaeffer E (2003). "Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells". J. Virol. 77 (9): 5415–27. doi:10.1128/JVI.77.9.5415-5427.2003. PMC 153947. PMID 12692243.
  • Senawong T, Peterson VJ, Avram D, Shepherd DM, Frye RA, Minucci S, Leid M (2003). "Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression". J. Biol. Chem. 278 (44): 43041–50. doi:10.1074/jbc.M307477200. PMC 2819354. PMID 12930829.
  • Bezrookove V, van Zelderen-Bhola SL, Brink A, Szuhai K, Raap AK, Barge R, Beverstock GC, Rosenberg C (2004). "A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene". Cancer Genet. Cytogenet. 149 (1): 72–6. doi:10.1016/S0165-4608(03)00302-9. PMID 15104287.
  • MacLeod RA, Nagel S, Drexler HG (2004). "BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia". Cancer Genet. Cytogenet. 153 (1): 88–9. doi:10.1016/j.cancergencyto.2004.02.020. PMID 15325104.
  • Przybylski GK, Dik WA, Wanzeck J, Grabarczyk P, Majunke S, Martin-Subero JI, Siebert R, Dölken G, Ludwig WD, Verhaaf B, van Dongen JJ, Schmidt CA, Langerak AW (2005). "Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL". Leukemia. 19 (2): 201–8. doi:10.1038/sj.leu.2403619. PMID 15668700.
  • Cismasiu VB, Adamo K, Gecewicz J, Duque J, Lin Q, Avram D (2005). "BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter". Oncogene. 24 (45): 6753–64. doi:10.1038/sj.onc.1208904. PMID 16091750.
  • Marban C, Suzanne S, Dequiedt F, de Walque S, Redel L, Van Lint C, Aunis D, Rohr O (2007). "Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing". EMBO J. 26 (2): 412–23. doi:10.1038/sj.emboj.7601516. PMC 1783449. PMID 17245431.
  • Nagel S, Scherr M, Kel A, Hornischer K, Crawford GE, Kaufmann M, Meyer C, Drexler HG, MacLeod RA (2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1". Cancer Res. 67 (4): 1461–71. doi:10.1158/0008-5472.CAN-06-2615. PMID 17308084.
  • Kamimura K, Mishima Y, Obata M, Endo T, Aoyagi Y, Kominami R (2007). "Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages". Oncogene. 26 (40): 5840–50. doi:10.1038/sj.onc.1210388. PMID 17369851.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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