POU4F3

POU4F3
Identifiers
AliasesPOU4F3, BRN3C, DFNA15, POU class 4 homeobox 3, DFNA42, DFNA52
External IDsMGI: 102523 HomoloGene: 2023 GeneCards: POU4F3
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q32Start146,338,839 bp[1]
End146,341,722 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5459

18998

Ensembl

ENSG00000091010

ENSMUSG00000024497

UniProt

Q15319

Q63955

RefSeq (mRNA)

NM_002700

NM_138945

RefSeq (protein)

NP_002691

NP_620395

Location (UCSC)Chr 5: 146.34 – 146.34 MbChr 18: 42.39 – 42.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000091010 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024497 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Vahava O, Morell R, Lynch ED, Weiss S, Kagan ME, Ahituv N, Morrow JE, Lee MK, Skvorak AB, Morton CC, Blumenfeld A, Frydman M, Friedman TB, King MC, Avraham KB (Apr 1998). "Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans". Science. 279 (5358): 1950–4. doi:10.1126/science.279.5358.1950. PMID 9506947.
  6. ↑ "Entrez Gene: POU4F3 POU domain, class 4, transcription factor 3".

Further reading

In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice
  • Nolan LS, Jagutpal SS, Cadge BA, et al. (2017). "Identification and functional analysis of common sequence variants in the DFNA15 gene, Brn-3c". Gene. 400 (1–2): 89–97. doi:10.1016/j.gene.2007.05.023. PMID 17611044.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Clough RL, Sud R, Davis-Silberman N, et al. (2004). "Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity". Biochem. Biophys. Res. Commun. 324 (1): 372–81. doi:10.1016/j.bbrc.2004.09.074. PMID 15465029.
  • Weiss S, Gottfried I, Mayrose I, et al. (2003). "The DFNA15 Deafness Mutation Affects POU4F3 Protein Stability, Localization, and Transcriptional Activity". Mol. Cell. Biol. 23 (22): 7957–64. doi:10.1128/MCB.23.22.7957-7964.2003. PMC 262385. PMID 14585957.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Leonard JH, Cook AL, Van Gele M, et al. (2002). "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma". Int. J. Cancer. 101 (2): 103–10. doi:10.1002/ijc.10554. PMID 12209986.
  • Erkman L, McEvilly RJ, Luo L, et al. (1996). "Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development". Nature. 381 (6583): 603–6. doi:10.1038/381603a0. PMID 8637595.
  • Xiang M, Zhou L, Macke JP, et al. (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons". J. Neurosci. 15 (7 Pt 1): 4762–85. PMID 7623109.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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