IRX2

IRX2
Identifiers
AliasesIRX2, IRXA2, iroquois homeobox 2
External IDsMGI: 1197526 HomoloGene: 56490 GeneCards: IRX2
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5p15.33Start2,745,845 bp[1]
End2,751,662 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

153572

16372

Ensembl

ENSG00000170561

ENSMUSG00000001504

UniProt

Q9BZI1

P81066

RefSeq (mRNA)

NM_001134222
NM_033267

NM_010574

RefSeq (protein)

NP_001127694
NP_150366

NP_034704

Location (UCSC)Chr 5: 2.75 – 2.75 MbChr 13: 72.63 – 72.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Iroquois-class homeodomain protein IRX-2, also known as Iroquois homeobox protein 2, is a protein that in humans is encoded by the IRX2 gene.[5][6]

Function

IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170561 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001504 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: iroquois homeobox 2".
  6. ↑ Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T (2001). "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes". Cytogenet. Cell Genet. 92 (3–4): 320–5. doi:10.1159/000056921. PMID 11435706.

Further reading

  • Lam CY, Tam PO, Fan DS, et al. (2008). "A genome-wide scan maps a novel high myopia locus to 5p15". Invest. Ophthalmol. Vis. Sci. 49 (9): 3768–78. doi:10.1167/iovs.07-1126. PMID 18421076.
  • Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests". European Journal of Human Genetics. 18 (7): 815–20. doi:10.1038/ejhg.2010.2. PMC 2987367. PMID 20125193.
  • Adamowicz M, Radlwimmer B, Rieker RJ, et al. (2006). "Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas". Genes Chromosomes Cancer. 45 (9): 829–38. doi:10.1002/gcc.20343. PMID 16752383.
  • Matsumoto K, Nishihara S, Kamimura M, et al. (2004). "The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation". Nat. Neurosci. 7 (6): 605–12. doi:10.1038/nn1249. PMID 15133517.
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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