SIX4

SIX4
Identifiers
Aliases	SIX4, AREC3, SIX homeobox 4
External IDs	MGI: 106034 HomoloGene: 69089 GeneCards: SIX4
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	60,724,348 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	73,113,456 bp[2]
Gene ontology
Molecular function	• sequence-specific DNA binding; • RNA polymerase II core promoter proximal region sequence-specific DNA binding; • transcription factor activity, sequence-specific DNA binding; • DNA binding; • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • transcription regulatory region sequence-specific DNA binding; • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;
Cellular component	• cytoplasm; • cell nucleus; • transcription factor complex;
Biological process	• tongue development; • trigeminal ganglion development; • sarcomere organization; • generation of neurons; • regulation of branch elongation involved in ureteric bud branching; • negative regulation of apoptotic process; • positive regulation of branching involved in ureteric bud morphogenesis; • transcription, DNA-templated; • multicellular organism development; • negative regulation of satellite cell differentiation; • pharyngeal system development; • anatomical structure morphogenesis; • embryonic skeletal system morphogenesis; • inner ear morphogenesis; • myotome development; • fungiform papilla morphogenesis; • skeletal muscle fiber differentiation; • positive regulation of ureteric bud formation; • regulation of gene expression; • embryonic cranial skeleton morphogenesis; • anatomical structure development; • regulation of synaptic growth at neuromuscular junction; • olfactory placode formation; • myoblast migration; • thymus development; • positive regulation of transcription, DNA-templated; • regulation of epithelial cell proliferation; • metanephric mesenchyme development; • male sex determination; • skeletal muscle tissue development; • negative regulation of neuron apoptotic process; • regulation of protein localization; • male sex differentiation; • regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter; • male gonad development; • negative regulation of transcription, DNA-templated; • protein localization to nucleus;
	Sources:Amigo / QuickGO
Orthologs
	51804
	20474
	ENSG00000100625
	ENSMUSG00000034460
	Q9UIU6
	Q61321
	NM_017420
	NM_011382; NM_001362272
	NP_059116
	NP_035512; NP_001349201
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein SIX4 is a protein that in humans is encoded by the SIX4 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100625 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034460 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Gallardo ME, Lopez-Rios J, Fernaud-Espinosa I, Granadino B, Sanz R, Ramos C, Ayuso C, Seller MJ, Brunner HG, Bovolenta P, Rodriguez de Cordoba S (Nov 1999). "Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies". Genomics. 61 (1): 82–91. doi:10.1006/geno.1999.5916. PMID 10512683.
↑ Ozaki H, Yamada K, Kobayashi M, Asakawa S, Minoshima S, Shimizu N, Kajitani M, Kawakami K (May 2000). "Structure and chromosome mapping of the human SIX4 and murine Six4 genes". Cytogenet Cell Genet. 87 (1–2): 108–12. doi:10.1159/000015407. PMID 10640827.
↑ "Entrez Gene: SIX4 sine oculis homeobox homolog 4 (Drosophila)".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
López-Ríos J, Tessmar K, Loosli F, et al. (2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development. 130 (1): 185–95. doi:10.1242/dev.00185. PMID 12441302.
Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein". Mol. Cell. Biol. 22 (19): 6759–66. doi:10.1128/MCB.22.19.6759-6766.2002. PMC 134036. PMID 12215533.
Fan X, Brass LF, Poncz M, et al. (2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137.
Kawakami K, Ohto H, Ikeda K, Roeder RG (1996). "Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development". Nucleic Acids Res. 24 (2): 303–10. doi:10.1093/nar/24.2.303. PMC 145635. PMID 8628654.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100625 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034460 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10512683-5] Gallardo ME, Lopez-Rios J, Fernaud-Espinosa I, Granadino B, Sanz R, Ramos C, Ayuso C, Seller MJ, Brunner HG, Bovolenta P, Rodriguez de Cordoba S (Nov 1999). "Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies". Genomics. 61 (1): 82–91. doi:10.1006/geno.1999.5916. PMID 10512683.

[pmid10640827-6] Ozaki H, Yamada K, Kobayashi M, Asakawa S, Minoshima S, Shimizu N, Kajitani M, Kawakami K (May 2000). "Structure and chromosome mapping of the human SIX4 and murine Six4 genes". Cytogenet Cell Genet. 87 (1–2): 108–12. doi:10.1159/000015407. PMID 10640827.

[entrez-7] "Entrez Gene: SIX4 sine oculis homeobox homolog 4 (Drosophila)".

SIX4

References

Further reading