STAT2

STAT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTAT2, ISGF-3, P113, STAT113, IMD44, signal transducer and activator of transcription 2
External IDsMGI: 103039 HomoloGene: 3952 GeneCards: STAT2
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.3Start56,341,597 bp[1]
End56,360,155 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6773

20847

Ensembl

ENSG00000170581

ENSMUSG00000040033

UniProt

P52630

Q9WVL2

RefSeq (mRNA)

NM_005419
NM_198332

NM_019963

RefSeq (protein)

NP_005410
NP_938146

n/a

Location (UCSC)Chr 12: 56.34 – 56.36 MbChr 10: 128.27 – 128.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene.[5][6] It is a member of the STAT protein family.

Function

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.[6]

Interactions

STAT2 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170581 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040033 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Yan R, Qureshi S, Zhong Z, Wen Z, Darnell JE (Feb 1995). "The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2". Nucleic Acids Research. 23 (3): 459–63. doi:10.1093/nar/23.3.459. PMC 306697. PMID 7885841.
  6. 1 2 "Entrez Gene: STAT2 signal transducer and activator of transcription 2, 113kDa".
  7. ↑ Bhattacharya S, Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston DM (Sep 1996). "Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha". Nature. 383 (6598): 344–7. doi:10.1038/383344a0. PMID 8848048.
  8. 1 2 Li X, Leung S, Kerr IM, Stark GR (Apr 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Molecular and Cellular Biology. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052. PMID 9121453.
  9. ↑ Uddin S, Chamdin A, Platanias LC (Oct 1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor". The Journal of Biological Chemistry. 270 (42): 24627–30. doi:10.1074/jbc.270.42.24627. PMID 7559568.
  10. ↑ Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (Mar 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein". The EMBO Journal. 15 (5): 1064–74. PMC 450004. PMID 8605876.
  11. ↑ Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (Mar 2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". The Journal of Biological Chemistry. 277 (12): 9713–21. doi:10.1074/jbc.M111161200. PMID 11786546.
  12. ↑ Horvath CM, Stark GR, Kerr IM, Darnell JE (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Molecular and Cellular Biology. 16 (12): 6957–64. doi:10.1128/mcb.16.12.6957. PMC 231699. PMID 8943351.
  13. ↑ Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC (Aug 1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". The Journal of Biological Chemistry. 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. PMID 9242679.
  14. ↑ Lau JF, Nusinzon I, Burakov D, Freedman LP, Horvath CM (Jan 2003). "Role of metazoan mediator proteins in interferon-responsive transcription". Molecular and Cellular Biology. 23 (2): 620–8. doi:10.1128/mcb.23.2.620-628.2003. PMC 151539. PMID 12509459.
  15. ↑ Huang M, Qian F, Hu Y, Ang C, Li Z, Wen Z (Oct 2002). "Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes". Nature Cell Biology. 4 (10): 774–81. doi:10.1038/ncb855. PMID 12244326.
  16. ↑ Li X, Leung S, Qureshi S, Darnell JE, Stark GR (Mar 1996). "Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha". The Journal of Biological Chemistry. 271 (10): 5790–4. doi:10.1074/jbc.271.10.5790. PMID 8621447.
  17. ↑ Dumler I, Kopmann A, Wagner K, Mayboroda OA, Jerke U, Dietz R, Haller H, Gulba DC (Aug 1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". The Journal of Biological Chemistry. 274 (34): 24059–65. doi:10.1074/jbc.274.34.24059. PMID 10446176.
  18. ↑ Fagerlund R, Mélen K, Kinnunen L, Julkunen I (Aug 2002). "Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5". The Journal of Biological Chemistry. 277 (33): 30072–8. doi:10.1074/jbc.M202943200. PMID 12048190.

Further reading

  • Cebulla CM, Miller DM, Sedmak DD (2000). "Viral inhibition of interferon signal transduction". Intervirology. 42 (5–6): 325–30. doi:10.1159/000053968. PMID 10702714.
  • Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (Feb 2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene. 285 (1–2): 1–24. doi:10.1016/S0378-1119(02)00398-0. PMID 12039028.
  • Fu XY, Schindler C, Improta T, Aebersold R, Darnell JE (Aug 1992). "The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction". Proceedings of the National Academy of Sciences of the United States of America. 89 (16): 7840–3. doi:10.1073/pnas.89.16.7840. PMC 49807. PMID 1502204.
  • Uddin S, Chamdin A, Platanias LC (Oct 1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor". The Journal of Biological Chemistry. 270 (42): 24627–30. doi:10.1074/jbc.270.42.24627. PMID 7559568.
  • Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, Bernstein KE (May 1995). "Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor". Nature. 375 (6528): 247–50. doi:10.1038/375247a0. PMID 7746328.
  • Sugiyama T, Nishio Y, Kishimoto T, Akira S (Mar 1996). "Identification of alternative splicing form of Stat2". FEBS Letters. 381 (3): 191–4. doi:10.1016/0014-5793(96)00121-4. PMID 8601453.
  • Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (Mar 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein". The EMBO Journal. 15 (5): 1064–74. PMC 450004. PMID 8605876.
  • Gupta S, Yan H, Wong LH, Ralph S, Krolewski J, Schindler C (Mar 1996). "The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals". The EMBO Journal. 15 (5): 1075–84. PMC 450005. PMID 8605877.
  • Li X, Leung S, Qureshi S, Darnell JE, Stark GR (Mar 1996). "Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha". The Journal of Biological Chemistry. 271 (10): 5790–4. doi:10.1074/jbc.271.10.5790. PMID 8621447.
  • Bhattacharya S, Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston DM (Sep 1996). "Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha". Nature. 383 (6598): 344–7. doi:10.1038/383344a0. PMID 8848048.
  • Horvath CM, Stark GR, Kerr IM, Darnell JE (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Molecular and Cellular Biology. 16 (12): 6957–64. doi:10.1128/mcb.16.12.6957. PMC 231699. PMID 8943351.
  • Bluyssen HA, Levy DE (Feb 1997). "Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA". The Journal of Biological Chemistry. 272 (7): 4600–5. doi:10.1074/jbc.272.7.4600. PMID 9020188.
  • Li X, Leung S, Kerr IM, Stark GR (Apr 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Molecular and Cellular Biology. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052. PMID 9121453.
  • Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC (Aug 1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". The Journal of Biological Chemistry. 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. PMID 9242679.
  • Mowen K, David M (Nov 1998). "Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1". The Journal of Biological Chemistry. 273 (46): 30073–6. doi:10.1074/jbc.273.46.30073. PMID 9804758.
  • Dumler I, Kopmann A, Wagner K, Mayboroda OA, Jerke U, Dietz R, Haller H, Gulba DC (Aug 1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". The Journal of Biological Chemistry. 274 (34): 24059–65. doi:10.1074/jbc.274.34.24059. PMID 10446176.
  • Paulson M, Pisharody S, Pan L, Guadagno S, Mui AL, Levy DE (Sep 1999). "Stat protein transactivation domains recruit p300/CBP through widely divergent sequences". The Journal of Biological Chemistry. 274 (36): 25343–9. doi:10.1074/jbc.274.36.25343. PMID 10464260.
  • Gupta S, Jiang M, Pernis AB (Oct 1999). "IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells". Journal of Immunology. 163 (7): 3834–41. PMID 10490982.
  • Vila-Coro AJ, Rodríguez-Frade JM, Martín De Ana A, Moreno-Ortíz MC, Martínez-A C, Mellado M (Oct 1999). "The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway". FASEB Journal. 13 (13): 1699–710. PMID 10506573.


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