EGR3

EGR3
Identifiers
AliasesEGR3, EGR-3, PILOT, early growth response 3
External IDsMGI: 1306780 HomoloGene: 37923 GeneCards: EGR3
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p21.3Start22,687,659 bp[1]
End22,693,302 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1960

13655

Ensembl

ENSG00000179388

ENSMUSG00000033730

UniProt

Q06889

P43300

RefSeq (mRNA)

NM_001199880
NM_001199881
NM_004430

NM_001289925
NM_001289927
NM_018781

RefSeq (protein)

NP_001186809
NP_001186810
NP_004421

NP_001276854
NP_001276856
NP_061251

Location (UCSC)Chr 8: 22.69 – 22.69 MbChr 14: 70.08 – 70.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.[5][6][7]

The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling biological rhythm. It may also play a role in muscle development.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000179388 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033730 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP (Aug 1991). "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors". Oncogene. 6 (6): 917–28. PMID 1906159.
  6. ↑ Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (May 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". J Biol Chem. 277 (22): 19482–19487. doi:10.1074/jbc.M201687200. PMID 11909874.
  7. 1 2 "Entrez Gene: EGR3 early growth response 3".

Further reading

  • Yamada K, Gerber DJ, Iwayama Y, et al. (2007). "Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 104 (8): 2815–2820. doi:10.1073/pnas.0610765104. PMC 1815264. PMID 17360599.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yoo YG, Lee MO (2004). "Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor". J. Biol. Chem. 279 (35): 36242–36249. doi:10.1074/jbc.M401290200. PMID 15173177.
  • Inoue A, Omoto Y, Yamaguchi Y, et al. (2005). "Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells". J. Mol. Endocrinol. 32 (3): 649–661. doi:10.1677/jme.0.0320649. PMID 15171706.
  • Liu D, Jia H, Holmes DI, et al. (2004). "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1". Arterioscler. Thromb. Vasc. Biol. 23 (11): 2002–2007. doi:10.1161/01.ATV.0000098644.03153.6F. PMID 14525795.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Tourtellotte WG, Milbrandt J (1998). "Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3". Nat. Genet. 20 (1): 87–91. doi:10.1038/1757. PMID 9731539.
  • Morris ME, Viswanathan N, Kuhlman S, et al. (1998). "A screen for genes induced in the suprachiasmatic nucleus by light". Science. 279 (5356): 1544–1547. doi:10.1126/science.279.5356.1544. PMID 9488654.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–828. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Mages HW, Stamminger T, Rilke O, et al. (1993). "Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells". Int. Immunol. 5 (1): 63–70. doi:10.1093/intimm/5.1.63. PMID 8443122.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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