NFATC4

NFATC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YRP
Identifiers
Aliases	NFATC4, NF-AT3, NF-ATC4, NFAT3, nuclear factor of activated T-cells 4, nuclear factor of activated T cells 4
External IDs	MGI: 1920431 HomoloGene: 3349 GeneCards: NFATC4
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,365,673 bp[1] End 24,379,604 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 55,823,144 bp[2] End 55,833,943 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • peroxisome proliferator activated receptor binding • chromatin binding Cellular component • transcription factor complex • cell nucleus • cytoplasm • cytosol • nuclear speck • nuclear transcription factor complex Biological process • cell differentiation • regulation of transcription, DNA-templated • cellular response to lithium ion • negative regulation of chromatin binding • cellular response to UV • negative regulation of Wnt signaling pathway • calcineurin-NFAT signaling cascade • positive regulation of apoptotic signaling pathway • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • negative regulation of protein binding • smooth muscle cell differentiation • transcription, DNA-templated • regulation of synaptic plasticity • negative regulation of synapse maturation • heart development • negative regulation of dendrite morphogenesis • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of tumor necrosis factor production • branching involved in blood vessel morphogenesis • cellular respiration • positive regulation of apoptotic process • inflammatory response • muscle cell development • positive regulation of transcription from RNA polymerase II promoter • negative regulation of pri-miRNA transcription from RNA polymerase II promoter • cellular response to ionomycin • cytokine production Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4776	73181
Ensembl	ENSG00000100968 ENSG00000285485	ENSMUSG00000023411
UniProt	Q14934	Q8K120
RefSeq (mRNA)	NM_001136022 NM_001198965 NM_001198966 NM_001198967 NM_001288802 NM_004554 NM_001320043 NM_001363681 NM_001363682	NM_001168346 NM_023699
RefSeq (protein)	NP_001129494 NP_001185894 NP_001185895 NP_001185896 NP_001275731 NP_001306972 NP_004545 NP_001350610 NP_001350611	NP_001161818 NP_076188
Location (UCSC)	Chr 14: 24.37 – 24.38 Mb	Chr 14: 55.82 – 55.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.^[5][6]

Function

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.^[6]

NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation. Indeed, NFAT3 (NFATc4) is an inhibitor of cell motility by blocking the expression of LCN2.^[7]

Interactions

NFATC4 has been shown to interact with CREB-binding protein.^[8]

See also

• NFAT

References

Further reading

External links

• NFATC4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.