ELF2

ELF2
Identifiers
AliasesELF2, EU32, NERF, NERF-1A, NERF-1B, NERF-1a,b, NERF-2, E74 like ETS transcription factor 2
External IDsMGI: 1916507 HomoloGene: 5006 GeneCards: ELF2
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q31.1Start139,028,112 bp[1]
End139,177,218 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

1998

69257

Ensembl

ENSG00000109381

ENSMUSG00000037174

UniProt

Q15723

Q9JHC9

RefSeq (mRNA)

NM_001291059
NM_001291062
NM_001291063
NM_023502
NM_001356358

RefSeq (protein)

NP_001277988
NP_001277991
NP_001277992
NP_075991
NP_001343287

Location (UCSC)Chr 4: 139.03 – 139.18 MbChr 3: 51.25 – 51.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor.[5] In humans this protein is encoded by the ELF2 gene.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000109381 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037174 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA (September 1996). "Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1". Mol. Cell. Biol. 16 (9): 5091–106. PMC 231510. PMID 8756667.
  6. ↑ "Entrez Gene: ELF2 E74-like factor 2 (ets domain transcription factor)".

Further reading

  • Wilkinson DA, Neale GA, Mao S, et al. (1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia". Leukemia. 11 (1): 86–96. doi:10.1038/sj.leu.2400516. PMID 9001422.
  • Mao S, Frank RC, Zhang J, et al. (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Mol. Cell. Biol. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
  • Christensen RA, Fujikawa K, Madore R, et al. (2002). "NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia". J. Cell. Biochem. 85 (3): 505–15. doi:10.1002/jcb.10148. PMID 11967990.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhang B, Tomita Y, Qiu Y, et al. (2007). "E74-like factor 2 regulates valosin-containing protein expression". Biochem. Biophys. Res. Commun. 356 (3): 536–41. doi:10.1016/j.bbrc.2007.02.160. PMID 17368566.


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