Cardiotrophin 1

cardiotrophin 1
Identifiers
Symbol CTF1, CT1, CT-1
Entrez 1489
HUGO 2499
OMIM 600435
RefSeq NM_001330
UniProt Q16619
Other data
Locus Chr. 16 p11.2-16p11.1

Cardiotrophin-1 (CT-1) is a cytokine. It is a cardiac hypertrophic factor of 21.5 kDa and a protein member of the IL-6 cytokine family.

Pathology

CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.

Mode of action

The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.

CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. [1]


References

  1. ↑ "Recombinant human Cardiotrophin 1 protein (ab9838)". www.abcam.com. Retrieved 2017-08-09.
  • cardiotrophin+1 at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Irving, Michael (August 8, 2017). "The protein that can make your heart think you exercise". newatlas.com. Retrieved 2017-08-09.
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