PRDM2

PRDM2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesPRDM2, HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2, PR domain 2, PR/SET domain 2, KMT8A
External IDsMGI: 107628 HomoloGene: 40822 GeneCards: PRDM2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.21Start13,700,198 bp[1]
End13,825,079 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7799

110593

Ensembl

ENSG00000116731

ENSMUSG00000057637

UniProt

Q13029

n/a

RefSeq (mRNA)

NM_001007257
NM_001135610
NM_012231
NM_015866

NM_001081355
NM_001256380

RefSeq (protein)

NP_001007258
NP_001129082
NP_036363
NP_056950

n/a

Location (UCSC)Chr 1: 13.7 – 13.83 MbChr 4: 143.11 – 143.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.[5][6]

Function

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

PRDM2 has been shown to interact with Estrogen receptor alpha[7] and Retinoblastoma protein.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000116731 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057637 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Buyse IM, Shao G, Huang S (May 1995). "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein". Proceedings of the National Academy of Sciences of the United States of America. 92 (10): 4467–71. doi:10.1073/pnas.92.10.4467. PMC 41965. PMID 7538672.
  6. 1 2 "Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain".
  7. ↑ Abbondanza C, Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA (Mar 2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3130–5. doi:10.1073/pnas.050015697. PMC 16204. PMID 10706618.

Further reading

  • Shapiro VS, Lee P, Winoto A (Oct 1995). "Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3". Gene. 163 (2): 329–30. doi:10.1016/0378-1119(95)00420-B. PMID 7590293.
  • Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S (Feb 1996). "cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene". European Journal of Biochemistry / FEBS. 235 (3): 471–9. doi:10.1111/j.1432-1033.1996.00471.x. PMID 8654390.
  • Buyse IM, Takahashi EI, Huang S (May 1996). "Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36". Genomics. 34 (1): 119–21. doi:10.1006/geno.1996.0249. PMID 8661032.
  • Liu L, Shao G, Steele-Perkins G, Huang S (Jan 1997). "The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter". The Journal of Biological Chemistry. 272 (5): 2984–91. doi:10.1074/jbc.272.5.2984. PMID 9006946.
  • Xie M, Shao G, Buyse IM, Huang S (Oct 1997). "Transcriptional repression mediated by the PR domain zinc finger gene RIZ". The Journal of Biological Chemistry. 272 (42): 26360–6. doi:10.1074/jbc.272.42.26360. PMID 9334209.
  • He L, Yu JX, Liu L, Buyse IM, Wang MS, Yang QC, Nakagawara A, Brodeur GM, Shi YE, Huang S (Oct 1998). "RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis". Cancer Research. 58 (19): 4238–44. PMID 9766644.
  • Abbondanza C, Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA (Mar 2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3130–5. doi:10.1073/pnas.050015697. PMC 16204. PMID 10706618.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S (Nov 2001). "Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily". Cancer Research. 61 (22): 8094–9. PMID 11719434.
  • Sasaki O, Meguro K, Tohmiya Y, Funato T, Shibahara S, Sasaki T (Mar 2002). "Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia". The Tohoku Journal of Experimental Medicine. 196 (3): 193–201. doi:10.1620/tjem.196.193. PMID 12002276.
  • Poetsch M, Dittberner T, Woenckhaus C (May 2002). "Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36". Oncogene. 21 (19): 3038–42. doi:10.1038/sj.onc.1205457. PMID 12082534.
  • Sasaki O, Meguro K, Tohmiya Y, Funato T, Shibahara S, Sasaki T (Dec 2002). "Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia". British Journal of Haematology. 119 (4): 940–8. doi:10.1046/j.1365-2141.2002.03972.x. PMID 12472571.
  • Tokumaru Y, Nomoto S, Jerónimo C, Henrique R, Harden S, Trink B, Sidransky D (Oct 2003). "Biallelic inactivation of the RIZ1 gene in human gastric cancer". Oncogene. 22 (44): 6954–8. doi:10.1038/sj.onc.1206403. PMID 14534544.
  • Kim KC, Geng L, Huang S (Nov 2003). "Inactivation of a histone methyltransferase by mutations in human cancers". Cancer Research. 63 (22): 7619–23. PMID 14633678.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Pan KF, Lu YY, Liu WG, Zhang L, You WC (Sep 2004). "Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability". World Journal of Gastroenterology. 10 (18): 2719–22. doi:10.3748/wjg.v10.i18.2719. PMID 15309726.
  • Rossi M, Abbondanza C, D'Arcangelo A, Gazzerro P, Medici N, Moncharmont B, Puca GA (Nov 2004). "The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation". Cancer Letters. 215 (2): 229–37. doi:10.1016/j.canlet.2004.05.014. PMID 15488642.
  • Grundberg E, Carling T, Brändström H, Huang S, Ribom EL, Ljunggren O, Mallmin H, Kindmark A (Dec 2004). "A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women". The Journal of Clinical Endocrinology and Metabolism. 89 (12): 6173–8. doi:10.1210/jc.2004-0403. PMID 15579774.

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