PKNOX1

PKNOX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPKNOX1, PREP1, pkonx1c, PBX/knotted 1 homeobox 1
External IDsMGI: 1201409 HomoloGene: 3363 GeneCards: PKNOX1
Gene location (Human)
Chr.Chromosome 21 (human)[1]
Band21q22.3Start42,974,510 bp[1]
End43,033,931 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5316

18771

Ensembl

ENSG00000160199

ENSMUSG00000006705

UniProt

P55347
Q96I87

O70477

RefSeq (mRNA)

NM_001286258
NM_004571
NM_001320694

NM_016670

RefSeq (protein)

NP_057879

Location (UCSC)Chr 21: 42.97 – 43.03 MbChr 17: 31.56 – 31.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein PKNOX1 is a protein that in humans is encoded by the PKNOX1 gene.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160199 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006705 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Berthelsen J, Viggiano L, Schulz H, Ferretti E, Consalez GG, Rocchi M, Blasi F (Apr 1998). "PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C". Genomics. 47 (2): 323–4. doi:10.1006/geno.1997.5086. PMID 9479508.
  6. ↑ "Entrez Gene: PKNOX1 PBX/knotted 1 homeobox 1".

Further reading

  • Allen TD, Zhu YX, Hawley TS, Hawley RG (2001). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leuk. Lymphoma. 39 (3–4): 241–56. doi:10.3109/10428190009065824. PMID 11342305.
  • Chang CP, Shen WF, Rozenfeld S, et al. (1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Phelan ML, Featherstone MS (1997). "Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers". J. Biol. Chem. 272 (13): 8635–43. doi:10.1074/jbc.272.13.8635. PMID 9079695.
  • Chen H, Rossier C, Nakamura Y, et al. (1997). "Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3". Genomics. 41 (2): 193–200. doi:10.1006/geno.1997.4632. PMID 9143494.
  • LeBrun DP, Matthews BP, Feldman BJ, Cleary ML (1997). "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains". Oncogene. 15 (17): 2059–67. doi:10.1038/sj.onc.1201367. PMID 9366523.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Berthelsen J, Zappavigna V, Mavilio F, Blasi F (1998). "Prep1, a novel functional partner of Pbx proteins". EMBO J. 17 (5): 1423–33. doi:10.1093/emboj/17.5.1423. PMC 1170490. PMID 9482739.
  • Berthelsen J, Zappavigna V, Ferretti E, et al. (1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMC 1170491. PMID 9482740.
  • Green NC, Rambaldi I, Teakles J, Featherstone MS (1998). "A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1". J. Biol. Chem. 273 (21): 13273–9. doi:10.1074/jbc.273.21.13273. PMID 9582372.
  • Berthelsen J, Kilstrup-Nielsen C, Blasi F, et al. (1999). "The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH". Genes Dev. 13 (8): 946–53. doi:10.1101/gad.13.8.946. PMC 316640. PMID 10215622.
  • Jacobs Y, Schnabel CA, Cleary ML (1999). "Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity". Mol. Cell. Biol. 19 (7): 5134–42. PMC 84356. PMID 10373562.
  • Knoepfler PS, Bergstrom DA, Uetsuki T, et al. (1999). "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1". Nucleic Acids Res. 27 (18): 3752–61. doi:10.1093/nar/27.18.3752. PMC 148632. PMID 10471746.
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
  • Kömüves LG, Shen WF, Kwong A, et al. (2000). "Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation". Dev. Dyn. 218 (4): 636–47. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1014>3.0.CO;2-I. PMID 10906782.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Okada Y, Matsuura E, Nagai R, et al. (2003). "PREP1, MEIS1 homolog protein, regulates PF4 gene expression". Biochem. Biophys. Res. Commun. 305 (1): 155–9. doi:10.1016/S0006-291X(03)00718-6. PMID 12732210.

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