DTX2

DTX2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDTX2, RNF58, deltex 2, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 2
External IDsMGI: 1921448 HomoloGene: 56904 GeneCards: DTX2
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q11.23Start76,461,676 bp[1]
End76,505,995 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

113878

74198

Ensembl

ENSG00000282379
ENSG00000091073

ENSMUSG00000004947

UniProt

Q86UW9

Q8R3P2

RefSeq (mRNA)

NM_001102594
NM_001102595
NM_001102596
NM_020892

NM_001256096
NM_001256097
NM_001256098
NM_023742

RefSeq (protein)

NP_001096064
NP_001096065
NP_001096066
NP_065943

NP_001243025
NP_001243026
NP_001243027
NP_076231

Location (UCSC)Chr 7: 76.46 – 76.51 MbChr 5: 135.99 – 136.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.[5]

DTX2 functions as a ubiquitin E3 ligase in conjunction with the E2 enzyme UBCH5A.[6]

References

  1. 1 2 3 ENSG00000091073 GRCh38: Ensembl release 89: ENSG00000282379, ENSG00000091073 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004947 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: DTX2 deltex homolog 2 (Drosophila)".
  6. ↑ Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.

Further reading

  • Matsuno K, Diederich RJ, Go MJ, et al. (1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development. 121 (8): 2633–44. PMID 7671825.
  • Kishi N, Tang Z, Maeda Y, et al. (2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". Int. J. Dev. Neurosci. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752.
  • Yamamoto N, Yamamoto S, Inagaki F, et al. (2002). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". J. Biol. Chem. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.
  • Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Hiller M, Huse K, Szafranski K, et al. (2007). "Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing". Am. J. Hum. Genet. 78 (2): 291–302. doi:10.1086/500151. PMC 1380236. PMID 16400609.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Yi Z, Yi T, Wu Z (2007). "cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos". DNA Seq. 17 (3): 175–80. doi:10.1080/10425170600857616. PMID 17286044.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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