DPF2

DPF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDPF2, REQ, UBID4, ubi-d4, double PHD fingers 2, CSS7
External IDsMGI: 109529 HomoloGene: 21265 GeneCards: DPF2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start65,333,754 bp[1]
End65,353,249 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5977

19708

Ensembl

ENSG00000133884

ENSMUSG00000024826

UniProt

Q92785

Q61103

RefSeq (mRNA)

NM_006268
NM_001330308

NM_001291078
NM_011262

RefSeq (protein)

NP_001317237
NP_006259
NP_006259.1

NP_001278007
NP_035392

Location (UCSC)Chr 11: 65.33 – 65.35 MbChr 19: 5.9 – 5.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.[5][6]

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000133884 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024826 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome. 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289.
  6. 1 2 "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2".

Further reading

  • Gabig TG, Mantel PL, Rosli R, Crean CD (1994). "Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells". J. Biol. Chem. 269 (47): 29515–9. PMID 7961935.
  • Chestkov AV, Baka ID, Kost MV, et al. (1997). "The d4 gene family in the human genome". Genomics. 36 (1): 174–7. doi:10.1006/geno.1996.0440. PMID 8812431.
  • Guru SC, Agarwal SK, Manickam P, et al. (1997). "A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
  • Gabig TG, Crean CD, Klenk A, et al. (1998). "Expression and chromosomal localization of the Requiem gene". Mamm. Genome. 9 (8): 660–5. doi:10.1007/s003359900840. PMID 9680388.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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