OR2H2

OR2H2
Identifiers
AliasesOR2H2, FAT11, OLFR2, OLFR42B, OR2H3, dJ271M21.2, hs6M1-12, olfactory receptor family 2 subfamily H member 2
External IDsMGI: 2177473 HomoloGene: 68546 GeneCards: OR2H2
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.1Start29,585,121 bp[1]
End29,590,500 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7932

258469

Ensembl

ENSMUSG00000056600

UniProt

O95918

n/a

RefSeq (mRNA)

NM_007160

NM_146477

RefSeq (protein)

NP_009091

n/a

Location (UCSC)Chr 6: 29.59 – 29.59 MbChr 17: 37.08 – 37.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2H2 is a protein that in humans is encoded by the OR2H2 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. 1 2 3 ENSG00000227044, ENSG00000204657, ENSG00000229185, ENSG00000229680, ENSG00000206467, ENSG00000224319 GRCh38: Ensembl release 89: ENSG00000206512, ENSG00000227044, ENSG00000204657, ENSG00000229185, ENSG00000229680, ENSG00000206467, ENSG00000224319 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056600 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: OR2H2 olfactory receptor, family 2, subfamily H, member 2".

Further reading

  • Fan W, Liu YC, Parimoo S, Weissman SM (1995). "Olfactory receptor-like genes are located in the human major histocompatibility complex". Genomics. 27 (1): 119–23. doi:10.1006/geno.1995.1013. PMID 7665158.
  • Fan W, Cai W, Parimoo S, et al. (1996). "Identification of seven new human MHC class I region genes around the HLA-F locus". Immunogenetics. 44 (2): 97–103. doi:10.1007/BF02660056. PMID 8662070.
  • Eklund AC, Belchak MM, Lapidos K, et al. (2000). "Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites". Hum. Immunol. 61 (7): 711–7. doi:10.1016/S0198-8859(00)00132-4. PMID 10880742.
  • Younger RM, Amadou C, Bethel G, et al. (2001). "Characterization of clustered MHC-linked olfactory receptor genes in human and mouse". Genome Res. 11 (4): 519–30. doi:10.1101/gr.160301. PMC 311051. PMID 11282967.
  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes". J. Biol. Chem. 278 (22): 19691–701. doi:10.1074/jbc.M212424200. PMID 12637542.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Santos PS, Kellermann T, Uchanska-Ziegler B, et al. (2010). "Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species". Immunogenetics. 62 (9): 569–84. doi:10.1007/s00251-010-0468-6. PMID 20680261.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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