OR2AG1

OR2AG1
Identifiers
AliasesOR2AG1, OR11-79, OR2AG3, olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene)
External IDsMGI: 3030539 HomoloGene: 128075 GeneCards: OR2AG1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.4Start6,783,020 bp[1]
End6,791,558 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

144125

259034

Ensembl

ENSG00000279486

ENSMUSG00000109058

UniProt

Q9H205

Q9EPF7

RefSeq (mRNA)

NM_001004489

NM_147032

RefSeq (protein)

NP_001004489

NP_667243

Location (UCSC)Chr 11: 6.78 – 6.79 MbChr 7: 106.87 – 106.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2AG1 is a protein that in humans is encoded by the OR2AG1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000279486 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000109058 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: OR2AG1 olfactory receptor, family 2, subfamily AG, member 1".

Further reading

  • Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390–5. doi:10.1073/pnas.131215398. PMC 34679. PMID 11416212.
  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Neuhaus EM, Mashukova A, Zhang W, et al. (2006). "A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins". Chem. Senses. 31 (5): 445–52. doi:10.1093/chemse/bjj049. PMID 16565291.
  • Mashukova A, Spehr M, Hatt H, Neuhaus EM (2006). "Beta-arrestin2-mediated internalization of mammalian odorant receptors". J. Neurosci. 26 (39): 9902–12. doi:10.1523/JNEUROSCI.2897-06.2006. PMID 17005854.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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