Pandemic predictions and preparations prior to the COVID-19 pandemic

Planning and preparing for pandemics has happened in countries and international organizations. The World Health Organization writes recommendations and guidelines, though there is no sustained mechanism to review countries' preparedness for epidemics and their rapid response abilities.[1] National action depends on national governments.[1]In 2005–2006, prior to the 2009 swine flu pandemic and during the decade following it, the governments in the United States,[2] France,[3] UK and others managed strategic health equipment stocks, but often reduced stocks after the 2009 pandemic in order to reduce costs.

A June 2018 review said that pandemic plans everywhere were inadequate, since natural viruses can emerge with over 50% case fatality rates, but health professionals and policy makers planned as if pandemics would never exceed the 2.5% case fatality rate of the 1918 pandemic.[4] In the years leading up to the COVID-19 pandemic, several governments ran demonstration exercises (including Crimson Contagion) which proved that most countries would be underprepared.[5][6] Neither governments nor big businesses took action.[7] Several reports underlined the inability of national governments to learn from the previous disease outbreaks, epidemics and pandemics. Richard Horton, editor-in-chief of The Lancet, described the "global response to SARS-CoV-2 [as] the greatest science policy failure in a generation".[8]

Early outbreaks in Hubei, Italy and Spain showed that several wealthy countries' health care systems were overwhelmed.[9] In developing countries with weaker medical infrastructure, equipment for intensive care beds and other medical needs, shortages were expected to occur earlier.[9]

International

The World Health Organization (WHO) and the World Bank warned about the risk of pandemics throughout the 2000s and the 2010s, especially after the 2002–2004 SARS outbreak. The Global Preparedness Monitoring Board released its first report in late 2019.[1] Private[10] initiatives also raised awareness about pandemic threats and needs for better preparedness. In 2018, the WHO coined the term, Disease X, which "represents the knowledge that a serious international epidemic could be caused by a pathogen currently unknown to cause human disease" in order to focus research and development on likely candidates for the next, at-the-time unknown, pandemic.[11]

International divisions and lack of suitable collaboration limited preparedness.[1] WHO's pandemic influenza preparedness project had a US$39 million two-year budget, out of WHO's 2020–2021 budget of US$4.8 billion.

A number of organizations have been involved for years preparing the world for epidemics and pandemics. Among those is the Coalition for Epidemic Preparedness Innovations, co-founded by the Bill & Melinda Gates Foundation, Wellcome Trust, the European Commission. Since 2017 the Coalition has tried to produce a platform approach for dealing with emerging epidemic disease such as COVID-19, which would enable rapid vaccine development and immunity research in response to outbreaks.[12][13]

Countries

France

Following warnings and increased preparedness in the 2000s, the 2009 swine flu pandemic led to rapid anti-pandemic reactions among the Western countries. The H1N1/09 virus strain with mild symptoms and low lethality eventually led to a backlash over public sector over-reactiveness, spending and the high cost of the 2009 flu vaccine. In the following years, national strategic stockpiles of medical equipment were not systematically renewed. In France, a 382 million purchase of masks, vaccines and others for H1N1 under the responsibility of the Minister of Health Roselyne Bachelot was widely criticized.[3][14]

The French health authorities decided in 2011 not to replenish their stocks in order to reduce acquisitions and storage costs and rely more on supplies from China and just-in-time logistics and distribute the responsibility to private companies on an optional basis.[3] The French strategic stockpile dropped in this period from one billion surgical masks and 600 million FFP2 masks in 2010 to 150 million and zero, respectively in early 2020.[3]

United Kingdom

Richard Horton, editor-in-chief of The Lancet, suggested that economic austerity policies played a role in the United Kingdom (UK) "failing to act upon the lessons" of the 2002–2004 SARS outbreak and of the UK being "poorly prepared" for the COVID-19 pandemic.[8]

The UK preparedness have been documented.[15]

United States

The US government updated its pandemic plan[16] and public guidelines[17] [18] in April 2017. In January 2017 it had updated its estimate of resource gaps[19] [20] and a list of issues for the US government to consider (called a playbook).[21] The plan and guidelines were public. The estimate of resources and list of issues were not public, though they were not classified and reporters have obtained them and made them public.ref name="nat5"/>[21]

The military's estimate of resource gaps in January 2017 noted "Deficiencies and vulnerabilities... lack of infrastructure, and PPE... and limited laboratory confirmatory testing... Medical systems may be overwhelmed by a dramatic increase in patient numbers. Staff availability may also be limited as medical personnel become infected."[20] In the final year of the administration of George W. Bush, the Biomedical Advanced Research and Development Authority (a division of the Department of Health and Human Services) "estimated that an additional 70,000 machines [ventilators] would be required in a moderate influenza pandemic."[22]

The list of issues, or playbook, covered normal conditions as well as pandemic conditions. During normal conditions, there was no discussion of estimating and building up stockpiles for use in emergencies.[21] In the United States; the Strategic National Stockpile's stock of masks used against the 2009 flu pandemic was not replenished by the Obama administration or by the Trump administration.[2]

The 2017 guidelines note that a vaccine for the 2009 H1N1pdm09 swine flu virus took eight months before it was available for distribution at the end of 2009.[17] A vaccine for the 2003 SARS virus took 13 years to develop, and was ready for human trials in 2016, which have not yet happened.[23][24] A vaccine for the 2009 MERS virus took ten years to develop, and began human trials in 2019.[25] Nevertheless, the guidelines said only six months would be needed to develop and distribute a vaccine for the next pandemic, telling schools and day cares they might need to close that long.[17] However the guidelines told businesses to expect only up to two weeks of school closures, saying employees might need to stay home two weeks with their children.[26]

The guidelines did not expect any business closures, although studies had long predicted 80% drops in arts, entertainment, and recreation[27], and 5% to 10% drops in other economic activity over a year, with more severe drops in peak months.[28] The pandemic preparation studies did not address government action to help business, nor the recovery path.[29]

The guidelines anticipated "during a pandemic, infection in a localized area can last about six to eight weeks."[16]

The 2017 guidelines listed steps which could take place, up to voluntary home isolation of sick people, and voluntary home quarantine of their contacts for up to three days.[17] There was no discussion or planning for closing businesses or ordering people to stay home, which may explain officials' delays in deciding on stay-at-home orders in the 2020 COVID-19 pandemic and lack of preparation to distinguish non-essential from essential workers, and to protect essential workers. In the 1918 flu pandemic many cities closed at least bars, for up to six weeks, and most cities had mandatory isolation and quarantine of sick people and their contacts.[30] Cities with the most severe closures had the best economic recovery.[31] [32]

The guidelines told businesses to be ready to keep workers 3 feet apart, though the guidelines said coughs and sneezes can send viruses six feet.[26] Research says sneezes can send droplets 27 feet, and they can lodge in ventilation systems.[33] [34] The guidelines did not consider distances between customers or between them and workers.

Since the late Cold War, Russia has led misinformation campaigns to raise mistrust in public health authorities, and to say that the AIDS pandemic, the 2009 swine flu pandemic, the Ebola outbreaks and COVID-19 pandemic were American-created bio-weapons.[35]

See also

References

  1. "Wanted: world leaders to answer the coronavirus pandemic alarm". South China Morning Post. 31 March 2020. Archived from the original on 9 April 2020. Retrieved 6 April 2020.
  2. Manjoo, Farhad (25 March 2020). "Opinion | How the World's Richest Country Ran Out of a 75-Cent Face Mask". The New York Times. ISSN 0362-4331. Archived from the original on 25 March 2020. Retrieved 25 March 2020.
  3. "Pénurie de masques : une responsabilité partagée par les gouvernements" [Lack of masks: a responsibility shared by governments]. Public Senat (in French). 23 March 2020. Archived from the original on 9 April 2020. Retrieved 6 April 2020.
  4. Kamradt-Scott, Adam (19 March 2020). "The Politics of Pandemic Influenza Preparedness". The Oxford Handbook of Global Health Politics. doi:10.1093/oxfordhb/9780190456818.001.0001/oxfordhb-9780190456818-e-32. Retrieved 4 June 2020.
  5. "Coronavirus Outbreak: A Cascade of Warnings, Heard but Unheeded". The New York Times. 19 March 2020. Archived from the original on 22 April 2020. Retrieved 25 March 2020.
  6. Stracqualursi, Veronica (19 March 2020). "New York Times: HHS' pandemic simulation showed how US was ill prepared for coronavirus". CNN. Archived from the original on 22 April 2020. Retrieved 25 March 2020.
  7. "How the greedy elite failed us, putting profit before pandemic preparedness". South China Morning Post. 6 April 2020. Archived from the original on 9 April 2020. Retrieved 9 April 2020.
  8. Horton, Richard (9 April 2020). "Coronavirus is the greatest global science policy failure in a generation". The Guardian. Archived from the original on 9 April 2020. Retrieved 9 April 2020.
  9. Whittington, Dale; Wu, Xun (30 March 2020). "Why coronavirus lockdowns will not be easy for developing countries, and what they can learn". South China Morning Post. Archived from the original on 30 March 2020. Retrieved 6 April 2020.
  10. Gates, Bill (2015), The next outbreak? We're not ready, archived from the original on 5 April 2020, retrieved 6 April 2020
  11. "List of Blueprint priority diseases". WHO. 2018. Archived from the original on 9 April 2020. Retrieved 10 April 2020.
  12. "Preparing for the Next Pandemic", Wall Street Journal, April 3, 2020
  13. Gates, Bill. "Preparing for the next epidemic: a first step", GatesNotes, Jan. 18, 2017
  14. BFMTV. "Pénurie de masques: pourquoi la France avait décidé de ne pas renouveler ses stocks il y a neuf ans" [Lack of masks: why France decided not to renew its stocks nine years ago] (in French). BFMTV. Archived from the original on 6 April 2020. Retrieved 6 April 2020.
  15. https://www.theguardian.com/world/2020/may/31/how-a-decade-of-privatisation-and-cuts-exposed-england-to-coronavirus
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  18. "Educational Materials - Nonpharmaceutical Interventions". CDC. 28 January 2019. Retrieved 13 April 2020.
  19. Klippenstine, Ken (1 April 2020). "The Military Knew Years Ago That a Coronavirus Was Coming". The Nation. Retrieved 13 April 2020.
  20. Northern Command, US DOD (6 January 2017). "Pandemic Influenza and Infectious Disease Response". Scribd. Retrieved 13 April 2020.
  21. "Playbook for early response to high-consequence emerging infectious disease threats and biological incidents" (PDF). 2017. Retrieved 13 April 2020.
  22. Kulish, Nicholas; Kliff, Sarah; Silver-Greenberg, Jessica (29 March 2020). "The U.S. Tried to Build a New Fleet of Ventilators. The Mission Failed". The New York Times. ISSN 0362-4331. Retrieved 12 April 2020.
  23. "Scientists were close to a coronavirus vaccine years ago. Then the money dried up". NBC. Retrieved 13 April 2020.
  24. "SARS vaccines: where are we?". Medscape. 2009. Retrieved 13 April 2020.
  25. Walter Reed Army Institute of Research (25 July 2019). "MERS-CoV vaccine is safe and induces strong immunity in Army-led first-in-human trial". Medial Xpress. Retrieved 13 April 2020.
  26. "Get Your Workplace Ready for Pandemic Flu" (PDF). CDC. April 2017. Retrieved 13 April 2020.
  27. McKenna, Maryn; 2007 (22 March 2007). "Pandemic could cause deep, uneven recession, group predicts". Center for Infectious Disease Research and Policy, U of MN. Retrieved 25 April 2020.CS1 maint: numeric names: authors list (link)
  28. Oct 17; 2008 (17 October 2008). "World Bank says flu pandemic could cost $3 trillion". Center for Infectious Disease Research and Policy, U of MN. Retrieved 25 April 2020.CS1 maint: numeric names: authors list (link)
  29. McKibben, Warwick, and Alexandra Sidorenko (February 2006). "Global Macroeconomic Consequences of Pandemic Influenza" (PDF). Australia National University. Retrieved 24 April 2020.
  30. Markel, Howard; Lipman, Harvey B.; Navarro, J. Alexander; Sloan, Alexandra; Michalsen, Joseph R.; Stern, Alexandra Minna; Cetron, Martin S. (8 August 2007). "Nonpharmaceutical Interventions Implemented by US Cities During the 1918-1919 Influenza Pandemic". JAMA. 298 (6): 644–654. doi:10.1001/jama.298.6.644. ISSN 0098-7484.
  31. Badger, Emily; Bui, Quoctrung (3 April 2020). "Cities That Went All In on Social Distancing in 1918 Emerged Stronger for It". The New York Times. ISSN 0362-4331. Retrieved 13 April 2020.
  32. Correia, Sergio; Luck, Stephan; Verner, Emil (30 March 2020). "Pandemics Depress the Economy, Public Health Interventions Do Not: Evidence from the 1918 Flu". Rochester, NY. Cite journal requires |journal= (help)
  33. Bourouiba, Lydia (26 March 2020). "Turbulent Gas Clouds and Respiratory Pathogen Emissions: Potential Implications for Reducing Transmission of COVID-19". JAMA. doi:10.1001/jama.2020.4756.
  34. Culver, Jordan. "6 feet enough for social distancing? MIT researcher says droplets carrying coronavirus can travel up to 27 feet". USA Today. Retrieved 13 April 2020.
  35. Broad, William J. (13 April 2020). "Putin's Long War Against American Science". The New York Times. ISSN 0362-4331. Archived from the original on 1 May 2020. Retrieved 13 April 2020.
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