FZD10

FZD10
Identifiers
AliasesFZD10, CD350, FZ-10, Fz10, FzE7, hFz10, frizzled class receptor 10
External IDsMGI: 2136761 HomoloGene: 21411 GeneCards: FZD10
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q24.33Start130,162,459 bp[1]
End130,165,740 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11211

93897

Ensembl

ENSG00000111432

ENSMUSG00000081683

UniProt

Q9ULW2

Q8BKG4

RefSeq (mRNA)

NM_007197

NM_175284

RefSeq (protein)

NP_009128

NP_780493

Location (UCSC)Chr 12: 130.16 – 130.17 MbChr 5: 128.6 – 128.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Frizzled-10 is a protein that in humans is encoded by the FZD10 gene.[5][6] FZD10 has also been designated as CD350 (cluster of differentiation 350).

Function

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000111432 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000081683 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M (Aug 1999). "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family". Biochemical and Biophysical Research Communications. 262 (1): 39–43. doi:10.1006/bbrc.1999.1161. PMID 10448064.
  6. 1 2 "Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)".

Further reading

  • Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (Jun 1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
  • Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Aug 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
  • Kumar S, Connor JR, Dodds RA, Halsey W, Van Horn M, Mao J, Sathe G, Mui P, Agarwal P, Badger AM, Lee JC, Gowen M, Lark MW (Oct 2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society. 9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID 11597177.
  • Terasaki H, Saitoh T, Shiokawa K, Katoh M (Feb 2002). "Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway". International Journal of Molecular Medicine. 9 (2): 107–12. doi:10.3892/ijmm.9.2.107. PMID 11786918.
  • Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
  • "Frizzled Receptors: FZD10". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  • FZD10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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