CD8A

CD8A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD8A, CD8, Leu2, MAL, p32, CD8a molecule
External IDsMGI: 88346 HomoloGene: 133777 GeneCards: CD8A
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p11.2Start86,784,610 bp[1]
End86,808,396 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

925

12525

Ensembl

ENSG00000153563

ENSMUSG00000053977

UniProt

P01732

P01731

RefSeq (mRNA)

NM_001145873
NM_001768
NM_171827

NM_001081110
NM_009857

RefSeq (protein)

NP_001139345
NP_001759
NP_741969

NP_001074579
NP_033987

Location (UCSC)Chr 2: 86.78 – 86.81 MbChr 6: 71.37 – 71.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD8a (Cluster of Differentiation 8a), is a human gene.[5]

Function

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.[5]

Interactions

CD8A has been shown to interact with:

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000153563 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053977 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: CD8A CD8a molecule".
  6. ↑ Doucey MA, Goffin L, Naeher D, Michielin O, Baumgärtner P, Guillaume P, Palmer E, Luescher IF (January 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5): 3257–64. doi:10.1074/jbc.M208119200. PMID 12215456.
  7. 1 2 Gao GF, Willcox BE, Wyer JR, Boulter JM, O'Callaghan CA, Maenaka K, Stuart DI, Jones EY, Van Der Merwe PA, Bell JI, Jakobsen BK (May 2000). "Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha". J. Biol. Chem. 275 (20): 15232–8. doi:10.1074/jbc.275.20.15232. PMID 10809759.
  8. ↑ Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen BK (June 1997). "Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2". Nature. 387 (6633): 630–4. doi:10.1038/42523. PMID 9177355.
  9. ↑ Sanders SK, Giblin PA, Kavathas P (September 1991). "Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts". J. Exp. Med. 174 (3): 737–40. doi:10.1084/jem.174.3.737. PMC 2118947. PMID 1908512.

Further reading

  • Parnes JR (1989). "Molecular biology and function of CD4 and CD8". Adv. Immunol. 44: 265–311. doi:10.1016/S0065-2776(08)60644-6. PMID 2493728.
  • Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
  • Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.
  • Nakayama K, Kawachi Y, Tokito S, Minami N, Yamamoto R, Imai T, Gachelin G, Nakauchi H (1992). "Recent duplication of the two human CD8 beta-chain genes". J. Immunol. 148 (6): 1919–27. PMID 1541829.
  • Leahy DJ, Axel R, Hendrickson WA (1992). "Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution". Cell. 68 (6): 1145–62. doi:10.1016/0092-8674(92)90085-Q. PMID 1547508.
  • Erickson JD, Trojanowski JQ, Eiden LE (1991). "Regional distribution and partial molecular characterization of CD4-related mRNA in human brain and peripheral tissues". Brain Res. Mol. Brain Res. 10 (1): 23–31. doi:10.1016/0169-328X(91)90052-Y. PMID 1676132.
  • Moebius U, Kober G, Griscelli AL, Hercend T, Meuer SC (1991). "Expression of different CD8 isoforms on distinct human lymphocyte subpopulations". Eur. J. Immunol. 21 (8): 1793–800. doi:10.1002/eji.1830210803. PMID 1831127.
  • Mittler RS, Rankin BM, Kiener PA (1991). "Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells". J. Immunol. 147 (10): 3434–40. PMID 1834739.
  • Sanders SK, Giblin PA, Kavathas P (1991). "Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts". J. Exp. Med. 174 (3): 737–40. doi:10.1084/jem.174.3.737. PMC 2118947. PMID 1908512.
  • Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE (1989). "The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3277–81. doi:10.1073/pnas.86.9.3277. PMC 287114. PMID 2470098.
  • Norment AM, Lonberg N, Lacy E, Littman DR (1989). "Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene". J. Immunol. 142 (9): 3312–9. PMID 2496167.
  • Nakayama K, Tokito S, Okumura K, Nakauchi H (1989). "Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8)". Immunogenetics. 30 (5): 393–7. doi:10.1007/BF02425282. PMID 2509342.
  • Giblin P, Ledbetter JA, Kavathas P (1989). "A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 998–1002. doi:10.1073/pnas.86.3.998. PMC 286608. PMID 2536941.
  • Aruffo A, Seed B (1989). "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts". J. Immunol. 143 (5): 1723–30. PMID 2701945.
  • Bowcock AM, Kavathas P, Margolskee RF, Herzenberg L, Cavalli-Sforza LL (1986). "An RFLP associated with pcDLeu2-14, a human T-cell differentiation antigen CD8 (Leu2) cDNA mapped to 2p12". Nucleic Acids Res. 14 (19): 7817. doi:10.1093/nar/14.19.7817. PMC 311807. PMID 2877435.
  • Norment AM, Littman DR (1989). "A second subunit of CD8 is expressed in human T cells". EMBO J. 7 (11): 3433–9. PMC 454842. PMID 3145195.
  • Littman DR, Thomas Y, Maddon PJ, Chess L, Axel R (1985). "The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes". Cell. 40 (2): 237–46. doi:10.1016/0092-8674(85)90138-2. PMID 3871356.
  • Sukhatme VP, Sizer KC, Vollmer AC, Hunkapiller T, Parnes JR (1985). "The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions". Cell. 40 (3): 591–7. doi:10.1016/0092-8674(85)90207-7. PMID 3918796.
  • Parnes JR, Sizer KC, Sukhatme VP, Hunkapiller T (1986). "Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone". Behring Inst. Mitt. (77): 48–55. PMID 3936473.

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