MRGPRX2

MRGPRX2
Identifiers
AliasesMRGPRX2, MGRG3, MRGX2, MAS related GPR family member X2
External IDsMGI: 3588270 HomoloGene: 24986 GeneCards: MRGPRX2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.1Start19,054,455 bp[1]
End19,060,681 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

117194

243978

Ensembl

ENSG00000183695

ENSMUSG00000074109

UniProt

Q96LB1

Q3UG50

RefSeq (mRNA)

NM_001303615
NM_054030

NM_001034868

RefSeq (protein)

NP_001290544
NP_473371

NP_001030040

Location (UCSC)Chr 11: 19.05 – 19.06 MbChr 7: 48.48 – 48.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.[5][6] Agonists are gyrase inhibitors like ciprofloxacine and non-steroidal neuromuscular blocking agents like atracurium as well as vancomycin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions.

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183695 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074109 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.
  6. ↑ "Entrez Gene: MRGPRX2 MAS-related GPR, member X2".

Further reading

  • Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Robas N, Mead E, Fidock M (2004). "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion". J. Biol. Chem. 278 (45): 44400–44404. doi:10.1074/jbc.M302456200. PMID 12915402.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yang S, Liu Y, Lin AA, et al. (2005). "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception". Gene. 352: 30–35. doi:10.1016/j.gene.2005.03.001. PMID 15862286.
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