GPR116

ADGRF5
Identifiers
Aliases	ADGRF5, KPG_001, GPR116, adhesion G protein-coupled receptor F5
External IDs	MGI: 2182928 HomoloGene: 9065 GeneCards: ADGRF5
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	46,954,943 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	43,459,557 bp[2]
Gene ontology
Molecular function	• G-protein coupled receptor activity; • transmembrane signaling receptor activity; • signal transducer activity;
Cellular component	• integral component of membrane; • cell surface; • plasma membrane; • apical part of cell; • cytoplasmic vesicle; • membrane;
Biological process	• surfactant homeostasis; • negative regulation of macrophage activation; • G-protein coupled receptor signaling pathway; • cell surface receptor signaling pathway; • energy reserve metabolic process; • regulation of lipid metabolic process; • fat cell differentiation; • positive regulation of phospholipid biosynthetic process; • glucose homeostasis; • signal transduction; • glomerular filtration; • erythrocyte development; • pharyngeal arch artery morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	221395
	224792
	ENSG00000069122
	ENSMUSG00000056492
	Q8IZF2
	G5E8Q8
	NM_001098518; NM_015234
	NM_001081178; NM_001357332
	NP_001091988; NP_056049
	NP_001074647; NP_001344261
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene.^[5]^[6]^[7] GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000069122 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056492 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4.
↑ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
↑ "Entrez Gene: GPR116 G protein-coupled receptor 116".
↑ Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10.1016/j.celrep.2013.04.019. PMC 3695742. PMID 23684610.
↑ Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7): e69451. doi:10.1371/journal.pone.0069451. PMC 3726689. PMID 23922714.

Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000069122 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056492 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[5] Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4.

[pmid12435584-6] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.

[entrez-7] "Entrez Gene: GPR116 G protein-coupled receptor 116".

[8] Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10.1016/j.celrep.2013.04.019. PMC 3695742. PMID 23684610.

[9] Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7): e69451. doi:10.1371/journal.pone.0069451. PMC 3726689. PMID 23922714.

GPR116

References

Further reading