TAS2R9

TAS2R9
Identifiers
AliasesTAS2R9, T2R9, TRB6, taste 2 receptor member 9
External IDsHomoloGene: 88893 GeneCards: TAS2R9
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.2Start10,809,094 bp[1]
End10,810,168 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

50835

n/a

Ensembl

ENSG00000273713
ENSG00000273086
ENSG00000121381

n/a

UniProt

Q9NYW1

n/a

RefSeq (mRNA)

NM_023917

n/a

RefSeq (protein)

NP_076406

n/a

Location (UCSC)Chr 12: 10.81 – 10.81 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Taste receptor type 2 member 9 is a protein that in humans is encoded by the TAS2R9 gene.[3][4][5]

Function

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.[5]

Polymorphisms in this gene have been associated with the perceived bitterness of sweetener acesulfame potassium.[6]

See also

References

  1. 1 2 3 ENSG00000273086, ENSG00000121381 GRCh38: Ensembl release 89: ENSG00000273713, ENSG00000273086, ENSG00000121381 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
  4. ↑ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.
  5. 1 2 "Entrez Gene: TAS2R9 taste receptor, type 2, member 9".
  6. ↑ Allen AL, McGeary JE, Knopik VS, Hayes JE (2013). "Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31". Chem. Senses. 38 (5): 379–89. doi:10.1093/chemse/bjt017. PMC 3657735. PMID 23599216.

Further reading

  • Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
  • Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
  • Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
  • Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.
  • Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
  • Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
  • Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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