LAIR2

LAIR2
Identifiers
AliasesLAIR2, CD306, leukocyte associated immunoglobulin like receptor 2
External IDsHomoloGene: 88663 GeneCards: LAIR2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.42Start54,497,879 bp[1]
End54,510,687 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3904

n/a

Ensembl

ENSG00000167618
ENSG00000275819
ENSG00000277335
ENSG00000274084

n/a

UniProt

Q6ISS4

n/a

RefSeq (mRNA)

NM_002288
NM_021270

n/a

RefSeq (protein)

NP_002279
NP_067154

n/a

Location (UCSC)Chr 19: 54.5 – 54.51 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.[3][4]

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene.[4]

References

  1. 1 2 3 ENSG00000275819, ENSG00000277335, ENSG00000274084 GRCh38: Ensembl release 89: ENSG00000167618, ENSG00000275819, ENSG00000277335, ENSG00000274084 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (Sep 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity. 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. PMID 9285412.
  4. 1 2 "Entrez Gene: LAIR2 leukocyte-associated immunoglobulin-like receptor 2".

Further reading

  • Lebbink RJ, van den Berg MC, de Ruiter T, et al. (2008). "The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction". J. Immunol. 180 (3): 1662–9. doi:10.4049/jimmunol.180.3.1662. PMID 18209062.
  • Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Meyaard L, van der Vuurst de Vries AR, de Ruiter T, et al. (2001). "The Epithelial Cellular Adhesion Molecule (EP-Cam) Is a Ligand for the Leukocyte-Associated Immunoglobulin-like Receptor (Lair)". J. Exp. Med. 194 (1): 107–12. doi:10.1084/jem.194.1.107. PMC 2193444. PMID 11435477. (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
  • Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842.
  • Meyaard L, Hurenkamp J, Clevers H, et al. (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. PMID 10229813.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.


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