Neuropeptides B/W receptor 2

NPBWR2
Identifiers
AliasesNPBWR2, GPR8, Neuropeptides B/W receptor 2, neuropeptides B and W receptor 2
External IDsHomoloGene: 128565 GeneCards: NPBWR2
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.33Start64,105,820 bp[1]
End64,107,171 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2832

n/a

Ensembl

ENSG00000125522
ENSG00000277339

n/a

UniProt

P48146

n/a

RefSeq (mRNA)

NM_005286

n/a

RefSeq (protein)

NP_005277

n/a

Location (UCSC)Chr 20: 64.11 – 64.11 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene.[3]

The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain.[3]

See also

References

  1. 1 2 3 ENSG00000277339 GRCh38: Ensembl release 89: ENSG00000125522, ENSG00000277339 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. 1 2 "Entrez Gene: NPBWR2 neuropeptides B/W receptor 2".
  • "Neuropeptide B/W Receptors: NPBW2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

  • O'Dowd BF, Scheideler MA, Nguyen T, et al. (1995). "The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain". Genomics. 28 (1): 84–91. doi:10.1006/geno.1995.1109. PMID 7590751.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
  • Shimomura Y, Harada M, Goto M, et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32. doi:10.1074/jbc.M205337200. PMID 12130646.
  • Brezillon S, Lannoy V, Franssen JD, et al. (2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Tanaka H, Yoshida T, Miyamoto N, et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. doi:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
  • Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.

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