Neuropeptide FF receptor 2

NPFFR2
Identifiers
AliasesNPFFR2, GPR74, HLWAR77, NPFF2, NPGPR, neuropeptide FF receptor 2
External IDsMGI: 1860130 HomoloGene: 56982 GeneCards: NPFFR2
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q13.3Start72,031,804 bp[1]
End72,148,067 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10886

104443

Ensembl

ENSG00000056291

ENSMUSG00000035528

UniProt

Q9Y5X5

Q924H0

RefSeq (mRNA)

NM_001144756
NM_004885
NM_053036

NM_133192

RefSeq (protein)

NP_001138228
NP_004876
NP_444264

NP_573455

Location (UCSC)Chr 4: 72.03 – 72.15 MbChr 5: 89.53 – 89.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene.[5]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000056291 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035528 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: NPFFR2 neuropeptide FF receptor 2".
  • "Neuropeptide FF Receptors: NPFF2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

  • Cikos S, Gregor P, Koppel J (1999). "Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta". Biochem. Biophys. Res. Commun. 256 (2): 352–6. doi:10.1006/bbrc.1999.0332. PMID 10079187.
  • Parker RM, Copeland NG, Eyre HJ, et al. (2000). "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family". Brain Res. Mol. Brain Res. 77 (2): 199–208. doi:10.1016/S0169-328X(00)00052-8. PMID 10837915.
  • Elshourbagy NA, Ames RS, Fitzgerald LR, et al. (2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc.M004515200. PMID 10851242.
  • Bonini JA, Jones KA, Adham N, et al. (2001). "Identification and characterization of two G protein-coupled receptors for neuropeptide FF". J. Biol. Chem. 275 (50): 39324–31. doi:10.1074/jbc.M004385200. PMID 11024015.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Laemmle B, Schindler M, Beilmann M, et al. (2003). "Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus". Regul. Pept. 111 (1–3): 21–9. doi:10.1016/S0167-0115(02)00220-3. PMID 12609745.
  • Engström M, Wurster S, Savola JM, Panula P (2004). "Functional properties of Pfr(Tic)amide and BIBP3226 at human neuropeptide FF2 receptors". Peptides. 24 (12): 1947–54. doi:10.1016/j.peptides.2003.10.009. PMID 15127947.
  • Mollereau C, Mazarguil H, Zajac JM, Roumy M (2005). "Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells". Mol. Pharmacol. 67 (3): 965–75. doi:10.1124/mol.104.004614. PMID 15608144.
  • Ankö ML, Panula P (2006). "Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line". J. Neurochem. 96 (2): 573–84. doi:10.1111/j.1471-4159.2005.03581.x. PMID 16336216.
  • Ankö ML, Ostergård M, Lintunen M, Panula P (2007). "Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression". FEBS Lett. 580 (30): 6955–60. doi:10.1016/j.febslet.2006.11.063. PMID 17157836.
  • Dahlman I, Dicker A, Jiao H, et al. (2007). "A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis". Am. J. Hum. Genet. 80 (6): 1115–24. doi:10.1086/518445. PMC 1867099. PMID 17503329.
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