ATP1B3

ATP1B3
Identifiers
AliasesATP1B3, ATPB-3, CD298, ATPase Na+/K+ transporting subunit beta 3
External IDsMGI: 107788 HomoloGene: 37510 GeneCards: ATP1B3
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q23Start141,876,124 bp[1]
End141,926,514 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

483

11933

Ensembl

ENSG00000069849

ENSMUSG00000032412

UniProt

P54709

P97370

RefSeq (mRNA)

NM_001679

NM_007502
NM_001357212
NM_001357213

RefSeq (protein)

NP_001670

NP_031528
NP_001344141
NP_001344142

Location (UCSC)Chr 3: 141.88 – 141.93 MbChr 9: 96.33 – 96.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene.[5][6][7] ATP1B3 has also been designated as CD298 (cluster of differentiation 298).

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000069849 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032412 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Malik N, Canfield VA, Beckers MC, Gros P, Levenson R (Nov 1996). "Identification of the mammalian Na,K-ATPase 3 subunit". J Biol Chem. 271 (37): 22754–8. doi:10.1074/jbc.271.37.22754. PMID 8798450.
  6. ↑ Malik N, Canfield V, Sanchez-Watts G, Watts AG, Scherer S, Beatty BG, Gros P, Levenson R (Mar 1998). "Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene". Mamm Genome. 9 (2): 136–43. doi:10.1007/s003359900704. PMID 9457675.
  7. 1 2 "Entrez Gene: ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide".

Further reading

  • Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na,K-ATPase". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 38: 37–89. doi:10.1016/S0079-6603(08)60708-4. ISBN 978-0-12-540038-1. PMID 2158121.
  • Jørgensen PL (1982). "Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+ +K+)-ATPase". Biochim. Biophys. Acta. 694 (1): 27–68. doi:10.1016/0304-4157(82)90013-2. PMID 6289898.
  • Chiampanichayakul S, Szekeres A, Khunkaewla P, et al. (2003). "Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation". Int. Immunol. 14 (12): 1407–14. doi:10.1093/intimm/dxf112. PMID 12456588.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
  • Chiampanichayakul S, Khunkaewla P, Pata S, Kasinrerk W (2007). "Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells". Tissue Antigens. 68 (6): 509–17. doi:10.1111/j.1399-0039.2006.00726.x. PMID 17176442.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Aughey RJ, Murphy KT, Clark SA, et al. (2007). "Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes". J. Appl. Physiol. 103 (1): 39–47. doi:10.1152/japplphysiol.00236.2006. PMID 17446412.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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