TAS2R3

TAS2R3
Identifiers
AliasesTAS2R3, T2R3, taste 2 receptor member 3
External IDsMGI: 3606604 HomoloGene: 23231 GeneCards: TAS2R3
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q34Start141,764,097 bp[1]
End141,765,197 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

50831

574417

Ensembl

ENSG00000127362

ENSMUSG00000052850

UniProt

Q9NYW6

Q7TQA7

RefSeq (mRNA)

NM_016943

NM_001025385

RefSeq (protein)

NP_058639

NP_001020556

Location (UCSC)Chr 7: 141.76 – 141.77 MbChr 6: 40.49 – 40.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.[5]

Function

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.[5]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000127362 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052850 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: TAS2R3 taste receptor, type 2, member 3".

Further reading

  • Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
  • Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
  • Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
  • Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
  • Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.
  • Firestein S (2000). "The good taste of genomics". Nature. 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221.
  • Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.
  • Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S (2001). "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting". Biochem. Biophys. Res. Commun. 285 (1): 147–51. doi:10.1006/bbrc.2001.5136. PMID 11437385.
  • Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
  • Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
  • Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.

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