Tachykinin receptor

tachykinin receptor 1
Identifiers
Symbol TACR1
Alt. symbols TAC1R
Entrez 6869
HUGO 11526
OMIM 162323
RefSeq NM_001058
UniProt P25103
Other data
Locus Chr. 2 p13.1-p12
tachykinin receptor 2
Identifiers
Symbol TACR2
Alt. symbols TAC2R, NKNAR
Entrez 6865
HUGO 11527
OMIM 162321
RefSeq NM_001057
UniProt P21452
Other data
Locus Chr. 10 q11-q21
tachykinin receptor 3
Identifiers
Symbol TACR3
Entrez 6870
HUGO 11528
OMIM 162332
RefSeq NM_001059
UniProt P29371
Other data
Locus Chr. 4 q25

There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).

Binding

The genes and receptor ligands are as follows:[1]

Receptor GenePreferred ligand
NK1TACR1substance P
NK2TACR2neurokinin A
NK3TACR3neurokinin B

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

See also

References

  1. ↑ Maggi CA (September 1995). "The mammalian tachykinin receptors". General Pharmacology. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.
  • "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  • Tachykinin+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.