CD151

CD151
Identifiers
AliasesCD151, GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24, CD151 molecule (Raph blood group)
External IDsOMIM: 602243 MGI: 1096360 HomoloGene: 20916 GeneCards: CD151
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.5Start832,843 bp[1]
End839,831 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

977

12476

Ensembl

ENSG00000177697

ENSMUSG00000025510

UniProt

P48509
Q6ZNZ0

O35566

RefSeq (mRNA)

NM_139030
NM_001039490
NM_004357
NM_139029

NM_001111049
NM_001111050
NM_009842

RefSeq (protein)

NP_001104519
NP_001104520
NP_033972

Location (UCSC)Chr 11: 0.83 – 0.84 MbChr 7: 141.47 – 141.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.[5]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[5]

Interactions

Fibrosarcoma cells, reportedly stained with an antibody binding to CD151 (green) and a dye for the nucleus (blue).

CD151 has been shown to interact with CD46.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000177697 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025510 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: CD151 CD151 molecule (Raph blood group)".
  6. ↑ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.

Further reading

  • Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. PMID 11739647.
  • Ashman LK (2003). "CD151". J. Biol. Regul. Homeost. Agents. 16 (3): 223–6. PMID 12456024.
  • Ashman LK, Aylett GW, Mehrabani PA, Bendall LJ, Niutta S, Cambareri AC, Cole SR, Berndt MC (1992). "The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen". Br. J. Haematol. 79 (2): 263–70. doi:10.1111/j.1365-2141.1991.tb04531.x. PMID 1958484.
  • Fitter S, Tetaz TJ, Berndt MC, Ashman LK (1995). "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3". Blood. 86 (4): 1348–55. PMID 7632941.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hasegawa H, Utsunomiya Y, Kishimoto K, Yanagisawa K, Fujita S (1996). "SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily". J. Virol. 70 (5): 3258–63. PMC 190191. PMID 8627808.
  • Hasegawa H, Kishimoto K, Yanagisawa K, Terasaki H, Shimadzu M, Fujita S (1997). "Assignment of SFA-1 (PETA-3), a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization". Genomics. 40 (1): 193–6. doi:10.1006/geno.1996.4563. PMID 9070943.
  • Sincock PM, Mayrhofer G, Ashman LK (1997). "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin". J. Histochem. Cytochem. 45 (4): 515–25. doi:10.1177/002215549704500404. PMID 9111230.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Fitter S, Seldin MF, Ashman LK (1998). "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms". Biochim. Biophys. Acta. 1398 (1): 75–85. doi:10.1016/S0167-4781(98)00034-7. PMID 9602068.
  • Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK (1999). "PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function". J. Cell Sci. 112 ( Pt 6): 833–44. PMID 10036233.
  • Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
  • Testa JE, Brooks PC, Lin JM, Quigley JP (1999). "Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis". Cancer Res. 59 (15): 3812–20. PMID 10447000.
  • Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A (2000). "The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes". J. Cell Biol. 149 (4): 969–82. doi:10.1083/jcb.149.4.969. PMC 2174566. PMID 10811835.
  • Whittock NV, McLean WH (2001). "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene". Biochem. Biophys. Res. Commun. 281 (2): 425–30. doi:10.1006/bbrc.2001.4384. PMID 11181065.
  • Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein E (2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". J. Biol. Chem. 276 (17): 14329–37. doi:10.1074/jbc.M011297200. PMID 11278880.
  • Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
  • Kohno M, Hasegawa H, Miyake M, Yamamoto T, Fujita S (2002). "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase". Int. J. Cancer. 97 (3): 336–43. doi:10.1002/ijc.1605. PMID 11774285.
  • Zhang XA, Kazarov AR, Yang X, Bontrager AL, Stipp CS, Hemler ME (2002). "Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis". Mol. Biol. Cell. 13 (1): 1–11. doi:10.1091/mbc.01-10-0481. PMC 65068. PMID 11809818.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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