Free fatty acid receptor

free fatty acid receptor 1
Identifiers
Symbol FFAR1, FFA1R
Alt. symbols GPR40
Entrez 2864
HUGO 4498
OMIM 603820
RefSeq NM_005303
UniProt O14842
Other data
Locus Chr. 19 q13.1
free fatty acid receptor 2
Identifiers
Symbol FFAR2
Alt. symbols GPR43, FFA2R
Entrez 2867
HUGO 4501
OMIM 603823
RefSeq NM_005306
UniProt O15552
Other data
Locus Chr. 19 q13.1
free fatty acid receptor 3
Identifiers
Symbol FFAR3
Alt. symbols GPR41, FFA3R
Entrez 2865
HUGO 4499
OMIM 603821
RefSeq NM_005304
UniProt O14843
Other data
Locus Chr. 19 q13.1
G protein-coupled receptor 42
Identifiers
Symbol GPR42
Alt. symbols GPR41L, FFAR1L
Entrez 2866
HUGO 4500
OMIM 603822
RefSeq NM_005305
UniProt O15529
Other data
Locus Chr. 19 q31.1

The free fatty acid receptor is a G-protein coupled receptor which binds free fatty acids.[1] There are four variants of the receptor, each encoded by a separate gene (FFAR1, FFAR2, FFAR3, FFAR4). Preliminary findings suggest that FFAR2 and FFAR3 may interact to form a FFAR2-FFAR3 receptor heteromer. [2]

References

  1. ↑ Covington DK, Briscoe CA, Brown AJ, Jayawickreme CK (2006). "The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing". Biochem. Soc. Trans. 34 (Pt 5): 770–3. doi:10.1042/BST0340770. PMID 17052194.
  2. ↑ Ang, Zhiwei; Xiong, Ding; Wu, Min; Ding, Jeak Ling (2017-09-07). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". The FASEB Journal. 32: –201700252RR. doi:10.1096/fj.201700252RR. ISSN 0892-6638. PMC 5731126. PMID 28883043. Retrieved 2017-09-10.
  • "Free Fatty Acid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  • FFAR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
  • G-protein+coupled+receptor+43,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
  • FFAR3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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