TAS2R50

TAS2R50
Identifiers
AliasesTAS2R50, T2R50, T2R51, TAS2R51, taste 2 receptor member 50
External IDsHomoloGene: 88474 GeneCards: TAS2R50
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.2Start10,985,913 bp[1]
End10,986,912 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

259296

n/a

Ensembl

ENSG00000212126
ENSG00000276167
ENSG00000273431

n/a

UniProt

P59544

n/a

RefSeq (mRNA)

NM_176890

n/a

RefSeq (protein)

NP_795371

n/a

Location (UCSC)Chr 12: 10.99 – 10.99 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Taste receptor type 2 member 50 is a protein that in humans is encoded by the TAS2R50 gene.[3][4][5][6]

Function

TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway.[4] See also TAS2R10.[6]

See also

References

  1. 1 2 3 ENSG00000276167, ENSG00000273431 GRCh38: Ensembl release 89: ENSG00000212126, ENSG00000276167, ENSG00000273431 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855.
  4. 1 2 Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (Feb 2003). "Identification and characterization of human taste receptor genes belonging to the TAS2R family". Cytogenet Genome Res. 98 (1): 45–53. doi:10.1159/000068546. PMID 12584440.
  5. ↑ Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP (Sep 2005). "Identification of Four Gene Variants Associated with Myocardial Infarction". Am J Hum Genet. 77 (4): 596–605. doi:10.1086/491674. PMC 1275608. PMID 16175505.
  6. 1 2 "Entrez Gene: TAS2R50 taste receptor, type 2, member 50".

Further reading

  • Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
  • Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
  • Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
  • Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
  • Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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