GPR3

GPR3
Identifiers
AliasesGPR3, ACCA, G protein-coupled receptor 3
External IDsMGI: 101908 HomoloGene: 31303 GeneCards: GPR3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.11Start27,392,644 bp[1]
End27,395,814 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2827

14748

Ensembl

ENSG00000181773

ENSMUSG00000049649

UniProt

P46089

P35413

RefSeq (mRNA)

NM_005281

NM_008154

RefSeq (protein)

NP_005272

NP_032180

Location (UCSC)Chr 1: 27.39 – 27.4 MbChr 4: 133.21 – 133.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene.[5][6] The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

Function

GPR3 activates adenylate cyclase in the absence of ligand.[7] GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue.[8] It has been proposed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are GPR3 ligands,[9][10] however this result was not confirmed in a β-arrestin recruitment assay.[11]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000181773 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049649 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.
  6. ↑ "Entrez Gene: GPR3 G protein-coupled receptor 3".
  7. ↑ Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F (August 1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". Biochem. J. 309 ( Pt 3) (Pt 3): 837–43. PMC 1135708. PMID 7639700.
  8. ↑ Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA (December 2004). "The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes". Science. 306 (5703): 1947–50. doi:10.1126/science.1103974. PMID 15591206.
  9. ↑ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cell. Signal. 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.
  10. ↑ Hinckley M, Vaccari S, Horner K, Chen R, Conti M (November 2005). "The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes". Dev. Biol. 287 (2): 249–61. doi:10.1016/j.ydbio.2005.08.019. PMID 16229830.
  11. ↑ Yin H, Chu A, Li W, Wang B, Shelton F, Otero F, Nguyen DG, Caldwell JS, Chen YA (May 2009). "Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay". J. Biol. Chem. 284 (18): 12328–38. doi:10.1074/jbc.M806516200. PMC 2673301. PMID 19286662.

Further reading

  • Eggerickx D, Denef JF, Labbe O, et al. (1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". Biochem. J. 309 ( Pt 3) (Pt 3): 837–43. PMC 1135708. PMID 7639700.
  • Iismaa TP, Kiefer J, Liu ML, et al. (1995). "Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system". Genomics. 24 (2): 391–4. doi:10.1006/geno.1994.1635. PMID 7698767.
  • Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990.
  • Song ZH, Modi W, Bonner TI (1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Uhlenbrock K, Huber J, Ardati A, et al. (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cell. Physiol. Biochem. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
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